Technology Process of 3(2H)-Pyridazinone,6-[2-(4-fluorophenyl)-2-oxoethyl]-2-(2-methylphenyl)-
There total 5 articles about 3(2H)-Pyridazinone,6-[2-(4-fluorophenyl)-2-oxoethyl]-2-(2-methylphenyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -8 - 6 °C / Large scale
2: acetic acid; sodium acetate / water / 5 h / 100 - 108 °C / Large scale
3: toluene-4-sulfonic acid / toluene / 12 h / 105 - 111 °C / Large scale
4: pyridine; copper diacetate / N,N-dimethyl-formamide / 37 h / 25 °C / Large scale
5: hydrogenchloride; water / methanol / 8 h / 25 °C / Large scale
With
pyridine; hydrogenchloride; water; copper diacetate; sodium acetate; toluene-4-sulfonic acid; acetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op300237b
- Guidance literature:
-
Multi-step reaction with 3 steps
1: toluene-4-sulfonic acid / toluene / 12 h / 105 - 111 °C / Large scale
2: pyridine; copper diacetate / N,N-dimethyl-formamide / 37 h / 25 °C / Large scale
3: hydrogenchloride; water / methanol / 8 h / 25 °C / Large scale
With
pyridine; hydrogenchloride; water; copper diacetate; toluene-4-sulfonic acid;
In
methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op300237b
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetic acid; sodium acetate / water / 5 h / 100 - 108 °C / Large scale
2: toluene-4-sulfonic acid / toluene / 12 h / 105 - 111 °C / Large scale
3: pyridine; copper diacetate / N,N-dimethyl-formamide / 37 h / 25 °C / Large scale
4: hydrogenchloride; water / methanol / 8 h / 25 °C / Large scale
With
pyridine; hydrogenchloride; water; copper diacetate; sodium acetate; toluene-4-sulfonic acid; acetic acid;
In
methanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op300237b
