4-Methyl-N-[(phenylmethoxy)carbonyl]-L-leucine

Base Information

Chemical Name:4-Methyl-N-[(phenylmethoxy)carbonyl]-L-leucine
CAS No.:88319-44-2
Molecular Formula:C15H21NO4
Molecular Weight:279.336
Hs Code.:
DSSTox Substance ID:DTXSID201246677

Synonyms:SCHEMBL2400100;ARVUWUDYYMENSJ-LBPRGKRZSA-N;DTXSID201246677;4-Methyl-N-[(phenylmethoxy)carbonyl]-L-leucine;EN300-7295449;2(S)-benzyloxycarbonylamino-4,4-dimethylpentanoic acid;(2S)-2-{[(benzyloxy)carbonyl]amino}-4,4-dimethylpentanoic acid;88319-44-2

Suppliers and Price of 4-Methyl-N-[(phenylmethoxy)carbonyl]-L-leucine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Methyl-N-[(phenylmethoxy)carbonyl]-L-leucine

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:279.14705815
Heavy Atom Count:20
Complexity:329

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)CC(C(=O)O)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES:CC(C)(C)C[C@@H](C(=O)O)NC(=O)OCC1=CC=CC=C1

Technology Process of 4-Methyl-N-[(phenylmethoxy)carbonyl]-L-leucine

There total 11 articles about 4-Methyl-N-[(phenylmethoxy)carbonyl]-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 57224-50-7
(S)-2-Amino-4,4-dimethyl-pentanoic acid

: 501-53-1,94274-21-2
benzyl chloroformate

: 88319-44-2,201677-20-5
2S-2-benzyloxycarbonylamino-2-t-butylmethyl-acetic acid

Guidance literature:: With sodium hydroxide; In water;

Reference yield:

: 39168-28-0
(E)-2-cyano-4,4-dimethyl-pent-2-enoic acid

: 88319-44-2,201677-20-5
N-benzoyloxycarbonyl-L-neopentylglycine

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / H₂ / palladium black / acetic acid / 11.5 h

2: 50 percent / H₂O₂ / aq. KOH / 2 h

3: 100 percent / Br₂/aq. NaOH / 2 h / 30 - 40 °C

4: Ac₂O / 2 h / 0 - 5 °C

5: 100 percent / 10percent Aq_.HBr / 2 h / 100 °C

6: Aq_. NaOH / 2 h / Ambient temperature

With sodium hydroxide; hydrogen bromide; hydrogen; dihydrogen peroxide; bromine; acetic anhydride; palladium; In potassium hydroxide; acetic acid;

Reference yield:

: 7065-46-5
3,3-dimethylbutanoic acid chloride

: 88319-44-2,201677-20-5
N-benzoyloxycarbonyl-L-neopentylglycine

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / H₂ / Pd/BaSO₄ / toluene / 5 h / 120 °C

2: NH₃ / H₂O; toluene / 3 h / 50 °C

3: Aq_. HCl / 2 h / 100 °C

4: Ac₂O / 2 h / 0 - 5 °C

5: 100 percent / 10percent Aq_.HBr / 2 h / 100 °C

6: Aq_. NaOH / 2 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; ammonia; hydrogen bromide; hydrogen; acetic anhydride; Pd-BaSO₄; In water; toluene;