Lamivudine, (+/-)-trans-

Base Information

Chemical Name:Lamivudine, (+/-)-trans-
CAS No.:136846-20-3
Deprecated CAS:146726-78-5
Molecular Formula:C₈H₁₁N₃O₃S
Molecular Weight:229.26
Hs Code.:
UNII:77ANF82R6X
Nikkaji Number:J458.526G
ChEMBL ID:CHEMBL89149
Mol file:136846-20-3.mol

Synonyms:136846-20-3;Lamivudine, (+/-)-trans-;(+/-)-trans-Lamivudine;131086-22-1;OxathiolanC-(-)-alpha;UNII-77ANF82R6X;Lamivudine impurity B [USP];4-Amino-1-((2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one;77ANF82R6X;Lamivudine impurity B RS [USP];4-amino-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;Lamivudine specified impurity B [EP];2(1H)-Pyrimidinone, 4-amino-1-((2R,5R)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, rel-;2(1H)-Pyrimidinone, 4-amino-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, trans-;4-Amino-1-((2RS,5RS)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one;(-)-(2S,5S)-1-(2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine;2(1H)-Pyrimidinone, 4-amino-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-, (2S-trans)-;(-)-(2S,5S)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine;2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2S-trans)-;5'-Epi-lamivudine;OxathiolanC-(-).a.;CHEMBL89149;(?)-alpha-D-BCH-189;SCHEMBL2305925;2 inverted exclamation mark -Epi-Lamivudine;LAMIVUDINE IMPURITY B [EP IMPURITY];LAMIVUDINE IMPURITY B [USP IMPURITY];Q27266574

Suppliers and Price of Lamivudine, (+/-)-trans-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2’-Epi-Lamivudine
0.25mg
$ 205.00

TRC
2’-Epi-Lamivudine
1mg
$ 770.00

Biosynth Carbosynth
2'-Epi-lamivudine
5 mg
$ 4400.00

Biosynth Carbosynth
2'-Epi-lamivudine
2 mg
$ 1900.00

Biosynth Carbosynth
2'-Epi-lamivudine
1 mg
$ 1150.00

Biosynth Carbosynth
2'-Epi-lamivudine
0.5 mg
$ 650.00

Biosynth Carbosynth
2'-Epi-lamivudine
0.25 mg
$ 380.00

Total 13 raw suppliers

Chemical Property of Lamivudine, (+/-)-trans-

Chemical Property:

Melting Point:172.6 °C(Solv: water (7732-18-5); methanol (67-56-1))
Boiling Point:475.4°Cat760mmHg
PKA:13.83±0.10(Predicted)
Flash Point:241.3°C
PSA：115.67000
Density:1.73g/cm³
LogP:-0.01290
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Water (Slightly)
XLogP3:-0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:229.05211239
Heavy Atom Count:15
Complexity:331

Purity/Quality:

99.0% Min ^*data from raw suppliers

2’-Epi-Lamivudine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC(S1)CO)N2C=CC(=NC2=O)N
Isomeric SMILES:C1[C@H](O[C@@H](S1)CO)N2C=CC(=NC2=O)N
Uses An epimer of Lamivudine (L172500); an antiviral that inhibits HIV-reverse transcriptase. 2’-Epi-Lamivudine (Lamivudine EP Impurity B) is an epimer of Lamivudine (L172500); an antiviral that inhibits HIV-reverse transcriptase.

Technology Process of Lamivudine, (+/-)-trans-

There total 26 articles about Lamivudine, (+/-)-trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%