2-FLUORO-6-METHYLBENZYLBROMIDE

Base Information

• Chemical Name: 2-FLUORO-6-METHYLBENZYLBROMIDE
• CAS No.: 886502-18-7
• Molecular Formula: C8H8BrF
• Molecular Weight: 203.054
• Hs Code.: 2903998090
• Mol file: 886502-18-7.mol

Synonyms:2-Fluoro-6-methylbenzylbromide;PC9288;2-(Bromomethyl)-3-fluorotoluene;

Chemical Property of 2-FLUORO-6-METHYLBENZYLBROMIDE

Chemical Property:

• Boiling Point: 216.7±25.0 °C(Predicted)
• PSA: 0.00000
• Density: 1.456±0.06 g/cm3(Predicted)
• LogP: 3.02900

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-6-methylbenzylbromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Fluoro-6-methylbenzyl bromide

Technology Process of 2-FLUORO-6-METHYLBENZYLBROMIDE

There total 1 articles about 2-FLUORO-6-METHYLBENZYLBROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-fluoro-6-methylbenzyl alcohol (478163-35-8) → 2-(bromomethyl)-1-fluoro-3-methyl-benzene (886502-18-7)

Guidance literature:

With carbon tetrabromide; 1,3-bis-(diphenylphosphino)propane; In dichloromethane; at 0 - 20 ℃;

Reference yield: 55.0%

2-(bromomethyl)-1-fluoro-3-methyl-benzene (886502-18-7) + C23H35ClN4O5Si → C31H42ClFN4O5Si

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

Reference yield:

2-(bromomethyl)-1-fluoro-3-methyl-benzene (886502-18-7) + 7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1H-oxazolo[5,4-c]quinolin-2-one → 7-(3,5-dimethylisoxazol-4-yl)-1-[(2-fluoro-6-methyl-phenyl)methyl]-8-methoxy-oxazolo[5,4-c]quinolin-2-one

Guidance literature:

With tetra-(n-butyl)ammonium iodide; caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

upstream raw materials:

2-fluoro-6-methylbenzyl alcohol

Refernces