(5R,6R)-5,6-bis(4-methoxyphenyl)-1,4-dioxan-2-one

Base Information

Chemical Name:(5R,6R)-5,6-bis(4-methoxyphenyl)-1,4-dioxan-2-one
CAS No.:886986-68-1
Molecular Formula:C18H18O5
Molecular Weight:314.338
Hs Code.:
DSSTox Substance ID:DTXSID30579951
Nikkaji Number:J2.410.503B
Wikidata:Q82470635

Synonyms:(5R,6R)-5,6-bis(4-methoxyphenyl)-1,4-dioxan-2-one;886986-68-1;DTXSID30579951

Suppliers and Price of (5R,6R)-5,6-bis(4-methoxyphenyl)-1,4-dioxan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R,6R)-5,6-bis(4-methoxyphenyl)-1,4-dioxan-2-one

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:314.11542367
Heavy Atom Count:23
Complexity:383

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2C(OC(=O)CO2)C3=CC=C(C=C3)OC
Isomeric SMILES:COC1=CC=C(C=C1)[C@@H]2[C@H](OC(=O)CO2)C3=CC=C(C=C3)OC

Technology Process of (5R,6R)-5,6-bis(4-methoxyphenyl)-1,4-dioxan-2-one

There total 1 articles about (5R,6R)-5,6-bis(4-methoxyphenyl)-1,4-dioxan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 66768-20-5
(R,R)-(+)-1,2-bis(4-methoxyphenyl)ethane-1,2-diol

: 886986-68-1
(5R,6R)-5,6-Bis-(4-methoxy-phenyl)-[1,4]dioxan-2-one

Guidance literature:: (R,R)-(+)-1,2-bis(4-methoxyphenyl)ethane-1,2-diol; With di(n-butyl)tin oxide; In toluene; for 18h; Heating;

bromoacetic acid tert-butyl ester; With tetra-(n-butyl)ammonium iodide; In toluene; for 4h; Further stages.; Heating;
DOI:10.1002/anie.200603353

Reference yield: 86.0%

: 886986-68-1
(5R,6R)-5,6-Bis-(4-methoxy-phenyl)-[1,4]dioxan-2-one

: 922523-30-6
C₁₅H₂₀O₂

: 922523-27-1
C₃₃H₃₈O₇

Guidance literature:: (5R,6R)-5,6-Bis-(4-methoxy-phenyl)-[1,4]dioxan-2-one; With triethylamine; In hexane; dichloromethane; for 2.33333h;

C₁₅H₂₀O₂; In dichloromethane; for 14h; Further stages.; cooling;
DOI:10.1002/anie.200603353

Reference yield:

: 886986-68-1
(5R,6R)-5,6-Bis-(4-methoxy-phenyl)-[1,4]dioxan-2-one

: 922523-31-7
C₃₄H₄₂O₈

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N; (cyclohexyl)2BOTf / CH₂Cl₂; hexane / 2.33 h

1.2: 86 percent / CH₂Cl₂ / 14 h / cooling

2.1: 17.1 mmol / NaH / various solvent(s) / 0.42 h

With sodium hydride; triethylamine; In hexane; dichloromethane;
DOI:10.1002/anie.200603353