Thymidine, 3'-[[[1-[5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-2-nitrophenyl]eth oxy]carbonyl]amino]-3'-deoxy-, 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Base Information

• Chemical Name: Thymidine, 3'-[[[1-[5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-2-nitrophenyl]eth oxy]carbonyl]amino]-3'-deoxy-, 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
• CAS No.: 892387-01-8
• Molecular Formula: C50H59N6O12P
• Molecular Weight: 967.025

Synonyms:

Chemical Property of Thymidine, 3'-[[[1-[5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-2-nitrophenyl]eth oxy]carbonyl]amino]-3'-deoxy-, 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Chemical Property:

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Useful:

Technology Process of Thymidine, 3'-[[[1-[5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-2-nitrophenyl]eth oxy]carbonyl]amino]-3'-deoxy-, 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

There total 3 articles about Thymidine, 3'-[[[1-[5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-2-nitrophenyl]eth oxy]carbonyl]amino]-3'-deoxy-, 5'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5'hO-dT-PC + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 5'pA-dT-PC (892387-01-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 10 ℃; for 1.5h;

DOI:10.1002/anie.200600804

Reference yield:

3'-amino-3'-deoxythymidine (52450-18-7) → 5'pA-dT-PC (892387-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / Et₃N / dimethylformamide / 12 h

2: 85 percent / DIEA / acetonitrile / 1.5 h / 0 - 10 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/anie.200600804

Reference yield:

carbonic acid 1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-nitro-phenyl}-ethyl ester 2,5-dioxo-pyrrolidin-1-yl ester (892386-99-1) → 5'pA-dT-PC (892387-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / Et₃N / dimethylformamide / 12 h

2: 85 percent / DIEA / acetonitrile / 1.5 h / 0 - 10 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/anie.200600804

upstream raw materials:

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

carbonic acid 1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-nitro-phenyl}-ethyl ester 2,5-dioxo-pyrrolidin-1-yl ester

3'-amino-3'-deoxythymidine

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