4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE HYDROCHLORIDE
• CAS No.: 89584-31-6
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131.175
• Hs Code.: 2933399090
• Mol file: 89584-31-6.mol

Synonyms:4-(hydroxymethyl)piperidin-4-ol;

Chemical Property of 4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE HYDROCHLORIDE

Chemical Property:

• PSA: 52.49000
• Density: 1.126±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 0.22400
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Hydroxymethyl)piperidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE HYDROCHLORIDE

There total 4 articles about 4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-hydroxy-4-(hydroxymethyl)-1-(phenylmethyl)piperidine (92197-36-9) → 4-(hydroxymethyl)piperidin-4-ol (89584-31-6)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 50 ℃; for 4h; under 2250.23 Torr;

Reference yield: 100.0%

→ 4-(hydroxymethyl)piperidin-4-ol (89584-31-6)

Guidance literature:

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 4-(hydroxymethyl)piperidin-4-ol (89584-31-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride; tetrabutylammomium bromide / dimethyl sulfoxide / 1 h / 0 °C

1.2: 1.5 h / 20 °C

2.1: sulfuric acid / 20 °C

3.1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 775.74 Torr

With sulfuric acid; 10 wt% Pd(OH)2 on carbon; tetrabutylammomium bromide; hydrogen; sodium hydride; In methanol; dimethyl sulfoxide;

upstream raw materials:

4-hydroxy-4-(hydroxymethyl)-1-(phenylmethyl)piperidine

1-phenylmethyl-4-piperidone

N-benzyl-1-oxa-6-azaspiro[2,5]-octane

Refernces

• 1、 -. "Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions". Page/Page column 159. . Retrieved 2008/06/13.
• 2、 -. "QUINOLONE ANTIBACTERIAL AGENTS". Page/Page column 85; 107. . Retrieved 2010/02/11.