7-Hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile

Base Information

• Chemical Name: 7-Hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile
• CAS No.: 89939-60-6
• Molecular Formula: C8H6N4O
• Molecular Weight: 174.15900
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID20384798,DTXSID901166002
• Wikidata: Q82177162
• Pharos Ligand ID: 1ZNSYUVSK4Y7
• ChEMBL ID: CHEMBL4448240
• Mol file: 89939-60-6.mol

Synonyms:7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile;89939-60-6;5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile;158664-14-3;5-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile;CHEMBL4448240;5-methyl-7-oxo-4H,7H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile;starbld0023105;Maybridge1_004411;Oprea1_045195;SCHEMBL16077836;SCHEMBL18343696;HMS554A11;AMY1743;DTXSID20384798;DTXSID901166002;BUTTPARK 134\40-75;BBL013204;BDBM50533313;MFCD00122900;MFCD07774548;STK597509;STL164013;AKOS005068347;AKOS005518553;KM 00650;VS-03702;CS-0080895;EN300-1129692;J-519268;3-Cyano-5-methyl-7-hydroxypyrazolo[1,5-a]pyrimidine;4,7-Dihydro-5-methyl-7-oxopyrazolo[1,5-a]pyrimidine-3-carbonitrile

Chemical Property of 7-Hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile

Chemical Property:

• PSA: 74.21000
• LogP: 0.61498
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 174.05416083
• Heavy Atom Count: 13
• Complexity: 421

Purity/Quality:

98%min ^*data from raw suppliers

7-Hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)N2C(=N1)C(=CN2)C#N

Technology Process of 7-Hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile

There total 3 articles about 7-Hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl acetoacetate (141-97-9) + 3-amino-4-cyano-2H-pyrazole (16617-46-2) → 7-hydroxy-5-methylpyrazolo<1,5-a>pyrimidine-3-carbonitrile (89939-60-6)

Guidance literature:

In acetic acid; for 4h; Reflux;

DOI:10.1007/s00044-011-9558-8

Reference yield: 85.0%

3-Amino-4-cyanopyrazole (16617-46-2,882231-01-8) + ethyl acetoacetate (141-97-9) → 7-hydroxy-5-methylpyrazolo<1,5-a>pyrimidine-3-carbonitrile (89939-60-6)

Guidance literature:

With acetic acid; for 3h; Heating;

Reference yield:

→ 7-hydroxy-5-methylpyrazolo<1,5-a>pyrimidine-3-carbonitrile (89939-60-6)

Guidance literature:

Acetessigsaeure-aethylester, 5-Amino-4-cyan-pyrazol, Eg. <Δ>;

upstream raw materials:

3-Amino-4-cyanopyrazole

ethyl acetoacetate

3-amino-4-cyano-2H-pyrazole

Downstream raw materials:

C₃₆H₃₇N₇O₂S

C₄₀H₃₇N₇O₂S

C₃₃H₃₁N₇O₂S

C₁₇H₁₇N₅O₃S