hainanolidol

Base Information

• Chemical Name: hainanolidol
• CAS No.: 73213-63-5
• Molecular Formula: C₁₉H₂₀O₄
• Molecular Weight: 312.365

Synonyms:Hainanolidol;

Chemical Property of hainanolidol

Chemical Property:

• Vapor Pressure: 1.15E-17mmHg at 25°C
• Boiling Point: 614.4°Cat760mmHg
• Flash Point: 229.8°C
• PSA: 63.60000
• Density: 1.37g/cm³
• LogP: 1.47970

Purity/Quality:

≥95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of hainanolidol

There total 25 articles about hainanolidol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C31H52O6Si2 → hainanolidol (73213-63-5)

Guidance literature:

C₃₁H₅₂O₆Si₂; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 50 ℃; for 16h; Sealed tube;

With p-toluenesulfonic acid monohydrate; In chloroform-d1; at 8 ℃; for 12h;

DOI:10.1021/ja406255j

Reference yield:

ethyl 2,3-bis((tert-butyldimethylsilyl)oxy)-4-methyl-1-(2-oxoethyl)-1,2,3,4,4a,5,6,7-octahydronaphthalene-4a-carboxylate → hainanolidol (73213-63-5)

Guidance literature:

Multi-step reaction with 16 steps

1.1: acetonitrile; tert-butyl alcohol; aq. phosphate buffer / 2 h / 0 - 20 °C

1.2: 20 °C

2.1: tert.-butylhydroperoxide / ethyl acetate / 0.33 h / 20 °C / Molecular sieve

2.2: 48 h / Molecular sieve

3.1: chloroform / 5 h / 60 °C

4.1: benzo[1,3,2]dioxaborole / 2 h / 0 - 20 °C

4.2: 1 h / 0 °C / Reflux

5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - 0 °C

5.2: 1 h / 0 °C

5.3: 2 h / 0 - 20 °C

6.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

6.2: 5 h / 0 - 20 °C

6.3: 0.5 h / 0 °C

7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / chloroform / 12 h / Reflux

8.1: tetrahydrofuran / 0.5 h / 0 °C

9.1: trichloroacetic acid / dichloromethane / 1 h / 20 °C

9.2: Reflux

10.1: boron trifluoride diethyl etherate / dichloromethane / 3 h / 0 - 20 °C

11.1: lithium diisopropyl amide; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 1 h / -78 °C

12.1: triethylamine; dmap / dichloromethane / 0.5 h / 0 °C

13.1: magnesium monoperoxyphthalate / dichloromethane / 0.5 h / 20 °C

14.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; samarium diiodide / methanol; tetrahydrofuran / 0.17 h / 0 °C

15.1: oxygen; 5,15,10,20-tetraphenylporphyrin / acetonitrile / 0 °C / Irradiation

16.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 16 h / 50 °C / Sealed tube

16.2: 12 h / 8 °C

With tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; n-butyllithium; samarium diiodide; boron trifluoride diethyl etherate; magnesium monoperoxyphthalate; oxygen; 5,15,10,20-tetraphenylporphyrin; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; trichloroacetic acid; benzo[1,3,2]dioxaborole; In tetrahydrofuran; methanol; aq. phosphate buffer; dichloromethane; chloroform; ethyl acetate; acetonitrile; tert-butyl alcohol;

DOI:10.1021/ja406255j

Reference yield:

ethyl 2,3-bis((tert-butyldimethylsilyl)oxy)-1-(2-(methoxy(methyl)amino)-2-oxoethyl)-4-methyl-1,2,3,4,4a,5,6,7-octahydronaphthalene-4a-carboxylate → hainanolidol (73213-63-5)

Guidance literature:

Multi-step reaction with 15 steps

1.1: tert.-butylhydroperoxide / ethyl acetate / 0.33 h / 20 °C / Molecular sieve

1.2: 48 h / Molecular sieve

2.1: chloroform / 5 h / 60 °C

3.1: benzo[1,3,2]dioxaborole / 2 h / 0 - 20 °C

3.2: 1 h / 0 °C / Reflux

4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 - 0 °C

4.2: 1 h / 0 °C

4.3: 2 h / 0 - 20 °C

5.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

5.2: 5 h / 0 - 20 °C

5.3: 0.5 h / 0 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / chloroform / 12 h / Reflux

7.1: tetrahydrofuran / 0.5 h / 0 °C

8.1: trichloroacetic acid / dichloromethane / 1 h / 20 °C

8.2: Reflux

9.1: boron trifluoride diethyl etherate / dichloromethane / 3 h / 0 - 20 °C

10.1: lithium diisopropyl amide; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 1 h / -78 °C

11.1: triethylamine; dmap / dichloromethane / 0.5 h / 0 °C

12.1: magnesium monoperoxyphthalate / dichloromethane / 0.5 h / 20 °C

13.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; samarium diiodide / methanol; tetrahydrofuran / 0.17 h / 0 °C

14.1: oxygen; 5,15,10,20-tetraphenylporphyrin / acetonitrile / 0 °C / Irradiation

15.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 16 h / 50 °C / Sealed tube

15.2: 12 h / 8 °C

With tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium tetrahydroborate; n-butyllithium; samarium diiodide; boron trifluoride diethyl etherate; magnesium monoperoxyphthalate; oxygen; 5,15,10,20-tetraphenylporphyrin; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium diisopropyl amide; trichloroacetic acid; benzo[1,3,2]dioxaborole; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; acetonitrile;

DOI:10.1021/ja406255j

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 73213-63-5 hainanolidol

Send

Send

Metric Ton KG G Pound L ML

Send

Send