Pitolisant Hydrochloride

Base Information

• Chemical Name: Pitolisant Hydrochloride
• CAS No.: 903576-44-3
• Molecular Formula: C17H26ClNO.ClH
• Molecular Weight: 332.30800
• European Community (EC) Number: 691-750-3
• UNII: YV33CH63HI
• ChEMBL ID: CHEMBL4164059
• DSSTox Substance ID: DTXSID50238098
• NCI Thesaurus Code: C170328
• RXCUI: 2197879
• Wikidata: Q27895485
• Mol file: 903576-44-3.mol

Synonyms:Pitolisant hydrochloride;903576-44-3;Ciproxidine;BF 2649;Pitolisant (hydrochloride);Pitolisant HCl;YV33CH63HI;BF 2649 hydrochloride;BF-2649 HYDROCHLORIDE;Pitolisant hydrochloride [USAN];1-(3-(3-(4-Chlorophenyl)propoxy)propyl)piperidine hydrochloride;Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-, hydrochloride;903576-44-3 (HCl);Wakix (TN);Pitolisant hydrochloride (USAN);1-[3-[3-(4-Chlorophenyl)propoxy]propyl]-piperidine hydrochloride;1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine hydrochloride;Piperidine, 1-(3-(3-(4-chlorophenyl)propoxy)propyl)-, hydrochloride;PIPERIDINE, 1-(3-(3-(4-CHLOROPHENYL)PROPOXY)PROPYL)-, HYDROCHLORIDE (1:1);1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine monohydrochloride;1-(3-(3-(4-CHLOROPHENYL)PROPOXY)PROPYL)PIPERIDINE MONOHYDROCHLORIDE;BF 2.649;UNII-YV33CH63HI;C17H27Cl2NO;SCHEMBL4591893;CHEMBL4164059;DTXSID50238098;Pitolisant;BF2649;AMY23423;BCP16427;EX-A1420;HY-12199B;PITOLISANT HYDROCHLORIDE [MI];s5926;AKOS024457784;CS-1501;SB17036;PITOLISANT HYDROCHLORIDE [WHO-DD];AC-36017;AS-72196;PITOLISANT HYDROCHLORIDE [ORANGE BOOK];C77058;D11490;A900088;Q27895485;1-[3-[3-(4-chlorophenyl)propoxy]propyl]piperidine;hydrochloride

Chemical Property of Pitolisant Hydrochloride

Chemical Property:

• PSA: 12.47000
• LogP: 4.90510
• Storage Temp.: Desiccate at RT
• Solubility.: ≥16.6 mg/mL in DMSO; ≥57.4 mg/mL in H2O; ≥94.2 mg/mL in EtOH
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 8
• Exact Mass: 331.1469699
• Heavy Atom Count: 21
• Complexity: 235

Purity/Quality:

99%, ^*data from raw suppliers

BF 2649 hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)CCCOCCCC2=CC=C(C=C2)Cl.Cl
• Recent ClinicalTrials: Dose Range Finding Study of BF2.649 Versus Placebo to Treat Excessive Daytime Sleepiness in Parkinson's Disease Patients
• Recent EU Clinical Trials: A Multisite Randomized, Double-Blind, Placebo-Controlled Trial
• Description: Pitolisant hydrochloride, a first-in-class inverse agonist of the histamine H3 receptor, was approved in the EU for the treatment of excessive daytime sleepiness (EDS) in adults with narcolepsy with or without cataplexy. The drug, which was developed by Bioprojet and has orphan drug designation in the EU and US, enhances wakefulness by increasing histaminergic neuron activity. With once daily oral administration in the morning, patients taking pitolisant exhibited significantly reduced EDS versus placebo but not versus modafinil. Plasma levels of the drug are reduced at the end of the day such that its waking effect is minimized at night (plasma t1/2 10-12 h). Several articles have been published detailing the discovery of pitolisant.
• Uses: BF 2649 Hydrochloride, is a novel histamine H3 receptor antagonist and inverse agonist.

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