4-Phenyl-3-furoxancarbonitrile

Base Information

• Chemical Name: 4-Phenyl-3-furoxancarbonitrile
• CAS No.: 125520-62-9
• Molecular Formula: C9H5 N3 O2
• Molecular Weight: 187.158
• Mol file: 125520-62-9.mol

Synonyms:Furazancarbonitrile,phenyl-, 2-oxide; RVC 589

Chemical Property of 4-Phenyl-3-furoxancarbonitrile

Chemical Property:

• Melting Point: 73-74oC
• Boiling Point: 415.3±47.0 °C(Predicted)
• PKA: -0.84±0.39(Predicted)
• PSA: 75.28000
• Density: 1.37±0.1 g/cm3(Predicted)
• LogP: 1.64178

Purity/Quality:

99% ^*data from raw suppliers

4-Phenyl-3-furoxancarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Able to activate the soluble guanylate cyclase by releasing Nitric Oxide under the action of thiol cofactors. Also inhibits platelet aggregation Able to activate the soluble guanylate cyclase by releasing Nitric Oxide under the action of thiol cofactors. Also inhibits platelet aggregation.

Technology Process of 4-Phenyl-3-furoxancarbonitrile

There total 19 articles about 4-Phenyl-3-furoxancarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-phenyl-3-furoxanylcarbaldehyde oxime (151733-56-1) → 4-phenyl-3-furoxancarbonitrile (125520-62-9)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

Reference yield: 91.0%

4-phenyl-3-furoxancarboxamide (125520-59-4) → 4-phenyl-3-furoxancarbonitrile (125520-62-9)

Guidance literature:

With pyridine; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.tet.2015.07.034

Reference yield:

2,2-dimethoxycyclohexanone oxime → 4-phenyl-3-furoxancarbonitrile (125520-62-9)

Guidance literature:

With chlorine; sodium hydrogencarbonate; In dichloromethane; water;

upstream raw materials:

3-phenyl-4-cyano-furoxan

4-phenyl-3-furoxancarboxamide

4-phenyl-3-furoxanylcarbaldehyde oxime

4-phenylfuroxan-3-carboxaldehyde

Downstream raw materials:

3-phenyl-4-cyano-furoxan

5-amino-3-phenyl-4-(phenylthio)isoxazole

4-phenyl-furazan-3-carbonitrile

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