2-(benzo[d]thiazol-2-yl)-5-broMophenol

Base Information

• Chemical Name: 2-(benzo[d]thiazol-2-yl)-5-broMophenol
• CAS No.: 90481-37-1
• Molecular Formula: C13H8BrNOS
• Molecular Weight: 306.183
• Mol file: 90481-37-1.mol

Synonyms:2-(Benzothiazol-2-yl)-5-bromophenol;2-(3-CHLOROPHENOXY)ETHANETHIOAMIDE;2-(2-benzothiazolyl)-5-bromoPhenol;

Chemical Property of 2-(benzo[d]thiazol-2-yl)-5-broMophenol

Chemical Property:

• Melting Point: 142-143℃ (polymorph)
• Boiling Point: 434.6±55.0 °C(Predicted)
• PKA: 7.11±0.35(Predicted)
• PSA: 61.36000
• Density: 1.644±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 4.43140

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(benzo[d]thiazol-2-yl)-5-broMophenol

There total 4 articles about 2-(benzo[d]thiazol-2-yl)-5-broMophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-bromosalicylaldehyde (22532-62-3) + 2-amino-benzenethiol (137-07-5) → 2-(2'-hydroxy-4-bromophenyl)benzothiazole (90481-37-1)

Guidance literature:

With Ag₂CO₃/celite; In ethanol; at 70 ℃; for 3h;

DOI:10.1007/s13738-015-0592-1

Reference yield: 67.0%

2-(4-bromophenyl)benzothiazole (19654-19-4) → 2-(2'-hydroxy-4-bromophenyl)benzothiazole (90481-37-1)

Guidance literature:

With (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; oxygen; palladium diacetate; potassium trifluoroacetate; trifluoroacetic acid; In N,N-dimethyl-formamide; at 70 ℃; for 24h; Irradiation;

DOI:10.1021/acs.joc.9b03197

Reference yield: 65.0%

4-bromosalicylic acid (1666-28-0) + 2-amino-benzenethiol (137-07-5) → 2-(2'-hydroxy-4-bromophenyl)benzothiazole (90481-37-1)

Guidance literature:

With polyphosphoric acid; at 180 ℃; for 24h;

upstream raw materials:

4-bromosalicylic acid

2-amino-benzenethiol

4-bromosalicylaldehyde

2-(4-bromophenyl)benzothiazole