Nitramisole

Base Information

• Chemical Name: Nitramisole
• CAS No.: 6363-02-6
• Molecular Formula: C11H11N3O2S
• Molecular Weight: 249.2889
• Mol file: 6363-02-6.mol

Synonyms:Nitramisole [INN];Nitramisol;Imidazo(2,1-b)thiazole,2,3,5,6-tetrahydro-6-(3-nitrophenyl);(+-)-2,3,5,6-Tetrahydro-6-(3-nitrophenyl)imidazo(2,1-b)thiazol;Nitramisolum;Nitramisole;

Chemical Property of Nitramisole

Chemical Property:

• Vapor Pressure: 5.86E-07mmHg at 25°C
• Boiling Point: 410.8°Cat760mmHg
• Flash Point: 202.2°C
• PSA: 86.72000
• Density: 1.56g/cm³
• LogP: 1.95100

Purity/Quality:

NITRAMISOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Anthelmintic.

Technology Process of Nitramisole

There total 7 articles about Nitramisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H13N3O3S (82191-15-9) → l-6-(m-nitrophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (6646-49-7,6363-02-6)

Guidance literature:

C₁₁H₁₃N₃O₃S; With thionyl chloride; In 1,2-dichloro-ethane; at 20 ℃;

With sodium hydrogencarbonate; In water; 1,2-dichloro-ethane; at 40 ℃; for 6h;

Reference yield:

3'-nitro-2-bromoacetophenone (2227-64-7) → l-6-(m-nitrophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (6646-49-7,6363-02-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 0.5 h / Heating

2: Py / CHCl₃ / 1.5 h / Heating

3: (i) SOCl₂, (ii) Ac₂O

With pyridine; In chloroform; acetonitrile;

DOI:10.1021/jm00322a023

Reference yield:

2-(2-imino-thiazolidin-3-yl)-1-(3-nitro-phenyl)-ethanone (83846-64-4) → l-6-(m-nitrophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole (6646-49-7,6363-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Py / CHCl₃ / 1.5 h / Heating

2: (i) SOCl₂, (ii) Ac₂O

With pyridine; In chloroform;

DOI:10.1021/jm00322a023

upstream raw materials:

2-(2-acetylimino-thiazolidin-3-yl)-1-(3-nitro-phenyl)-ethanone

2-(2-imino-thiazolidin-3-yl)-1-(3-nitro-phenyl)-ethanone

3'-nitro-2-bromoacetophenone

C₁₁H₁₃N₃O₃S

Downstream raw materials:

(6R)-(3-nitrophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole

(6S)-(3-nitrophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole

Refernces

• 1、 -. "6-Substituted amino phenyl-2,3,5,6-tetrahydro[2,1-b]thiazoles". . . Retrieved 2008/06/13.