4-methyl-1,2-benzenedimethanol

Base Information

• Chemical Name: 4-methyl-1,2-benzenedimethanol
• CAS No.: 90534-49-9
• Molecular Formula: C9H12O2
• Molecular Weight: 152.193
• Mol file: 90534-49-9.mol

Synonyms:2-(hydroxymethyl)-4-methylbenzyl alcohol;1,2-bishydroxymethyl-4-methylbenzene;(4-methyl-1,2-phenylene)dimethanol;((4-methyl-2-hydroxymethyl)phenyl)methanol;3,4-dihydroxymethyltoluene;4-methyl-1,2-benzenedimethanol;1,2-Benzenedimethanol,4-methyl;

Chemical Property of 4-methyl-1,2-benzenedimethanol

Chemical Property:

• PSA: 40.46000
• LogP: 0.97960

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methyl-1,2-benzenedimethanol

There total 5 articles about 4-methyl-1,2-benzenedimethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methylphthalic anhydride (19438-61-0) → 1,2-bishydroxymethyl-4-methylbenzene (90534-49-9)

Guidance literature:

With lithium aluminium tetrahydride; zinc(II) chloride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.3987/COM-08-S(F)85

Reference yield: 87.0%

4-methylphthalic acid (4316-23-8) → 1,2-bishydroxymethyl-4-methylbenzene (90534-49-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; -78 to 0 deg C, 2 h; reflux, overnight;

DOI:10.1055/s-1994-25632

Reference yield: 86.0%

dimethyl 4-methylphthalate (20116-65-8) → 1,2-bishydroxymethyl-4-methylbenzene (90534-49-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 20 ℃; for 19h; Heating / reflux;

upstream raw materials:

4-methylphthalic anhydride

4-methylphthalic acid

dimethyl 4-methylphthalate

6-methylisobenzofuran-1(3H)-one

Downstream raw materials:

4-methylbenzene-1,2-dicarbaldehyde

5-methylphthalide

6-methylisobenzofuran-1(3H)-one

1,2-bischloromethyl-4-methylbenzene

Refernces

• 1、 Ban, Kazuho,Sajiki, Hironao,Sawama, Yoshinari,Takakura, Ryoya. "Platinum-on-Carbon-Catalyzed Aqueous Oxidative Lactonization of Diols by Using Molecular Oxygen". supporting information. p. 1919 - 1923. Retrieved 2019/09/30.
• 2、 D'Hollander, Agathe C.A.,Westwood, Nicholas J.. "Assessment of the regioselectivity in the condensation reaction of unsymmetrical o-phthaldialdehydes with alanine". supporting information. p. 224 - 239. Retrieved 2017/12/08.