L-Alanine, N-[1-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-S-[(4-methylphenyl)methyl] -L-cysteinyl]-S-[(4-methylphenyl)methyl]-L-cysteinyl]-L-tyrosyl]-L-prolyl]-, methyl ester

Base Information

• Chemical Name: L-Alanine, N-[1-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-S-[(4-methylphenyl)methyl] -L-cysteinyl]-S-[(4-methylphenyl)methyl]-L-cysteinyl]-L-tyrosyl]-L-prolyl]-, methyl ester
• CAS No.: 90544-97-1
• Molecular Formula: C45H59N5O9S2
• Molecular Weight: 878.124
• Mol file: 90544-97-1.mol

Synonyms:

Chemical Property of L-Alanine, N-[1-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-S-[(4-methylphenyl)methyl] -L-cysteinyl]-S-[(4-methylphenyl)methyl]-L-cysteinyl]-L-tyrosyl]-L-prolyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Alanine, N-[1-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-S-[(4-methylphenyl)methyl] -L-cysteinyl]-S-[(4-methylphenyl)methyl]-L-cysteinyl]-L-tyrosyl]-L-prolyl]-, methyl ester

There total 2 articles about L-Alanine, N-[1-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-S-[(4-methylphenyl)methyl] -L-cysteinyl]-S-[(4-methylphenyl)methyl]-L-cysteinyl]-L-tyrosyl]-L-prolyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-L-proline-L-alanine methyl ester (51782-87-7) → (S)-2-({(S)-1-[(S)-2-[(R)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-methyl-benzylsulfanyl)-propionylamino]-3-(4-methyl-benzylsulfanyl)-propionylamino]-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-propionic acid methyl ester (90544-97-1)

Guidance literature:

DOI:10.1246/bcsj.57.125

Reference yield:

Boc-Cys(MeBzl)-Cys(MeBzl)-NHNH2 (90545-14-5) + (S)-2-({(S)-1-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-propionic acid methyl ester (90544-96-0) → (S)-2-({(S)-1-[(S)-2-[(R)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-methyl-benzylsulfanyl)-propionylamino]-3-(4-methyl-benzylsulfanyl)-propionylamino]-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-propionic acid methyl ester (90544-97-1)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1246/bcsj.57.125

Reference yield: 81.0%

(S)-2-({(S)-1-[(S)-2-[(R)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-methyl-benzylsulfanyl)-propionylamino]-3-(4-methyl-benzylsulfanyl)-propionylamino]-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-propionic acid methyl ester (90544-97-1) → [(R)-1-[(R)-1-[(S)-2-[(S)-2-((S)-1-Hydrazinocarbonyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1-(4-hydroxy-benzyl)-2-oxo-ethylcarbamoyl]-2-(4-methyl-benzylsulfanyl)-ethylcarbamoyl]-2-(4-methyl-benzylsulfanyl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:

With hydrazine hydrate; In methanol; for 24h; Ambient temperature;

DOI:10.1246/bcsj.57.125

upstream raw materials:

Boc-Cys(MeBzl)-Cys(MeBzl)-NHNH₂

(S)-2-({(S)-1-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-propionic acid methyl ester

Cbz-L-proline-L-alanine methyl ester