L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-

Base Information

Chemical Name:L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-
CAS No.:59749-23-4
Molecular Formula:C12H11Cl2NO3
Molecular Weight:288.13
Hs Code.:
DSSTox Substance ID:DTXSID00208468
Wikidata:Q76150757

Synonyms:BRN 4484137;L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-;1-((3,4-Dichlorophenyl)methyl)-5-oxo-L-proline;59749-23-4;Acide N-(dichloro-3',4' benzyl)pyroglutamique [French];Acide N-(dichloro-3',4' benzyl)pyroglutamique;C12H11Cl2NO3;DTXSID00208468;LS-118925

Suppliers and Price of L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-

Chemical Property:

Vapor Pressure:9.88E-12mmHg at 25°C
Boiling Point:522.2°Cat760mmHg
Flash Point:269.6°C
Density:1.51g/cm³
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:287.0115986
Heavy Atom Count:18
Complexity:350

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)N(C1C(=O)O)CC2=CC(=C(C=C2)Cl)Cl
Isomeric SMILES:C1CC(=O)N([C@@H]1C(=O)O)CC2=CC(=C(C=C2)Cl)Cl

Technology Process of L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo-

There total 3 articles about L-Proline, 1-((3,4-dichlorophenyl)methyl)-5-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59749-19-8
C₁₃H₁₃Cl₂NO₃

: 59749-23-4
(2S)-N-(3,4-dichloro-phenylmethyl)pyroglutamic acid

Guidance literature:: With water; sodium carbonate; In methanol; at 0 - 20 ℃; for 5h;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 18880-04-1
3,4-dichlorobenzyl bromide

: 59749-23-4
(2S)-N-(3,4-dichloro-phenylmethyl)pyroglutamic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium carbonate; water / methanol / 5 h / 0 - 20 °C

With water; sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 4931-66-2
methyl (S)-pyroglutamate

: 59749-23-4
(2S)-N-(3,4-dichloro-phenylmethyl)pyroglutamic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium carbonate; water / methanol / 5 h / 0 - 20 °C

With water; sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.1016/j.ejmech.2014.05.017