2-CHLORO-5-METHYL-4-PHENYLTHIAZOLE

Base Information

• Chemical Name: 2-CHLORO-5-METHYL-4-PHENYLTHIAZOLE
• CAS No.: 31784-90-4
• Molecular Formula: C₁₀H₈ClNS
• Molecular Weight: 209.699
• Hs Code.: 2934100090
• Mol file: 31784-90-4.mol

Synonyms:2-Chloro-4-phenyl-5-methylthiazole

Chemical Property of 2-CHLORO-5-METHYL-4-PHENYLTHIAZOLE

Chemical Property:

• Vapor Pressure: 0.00036mmHg at 25°C
• Boiling Point: 328.5°Cat760mmHg
• Flash Point: 152.5°C
• PSA: 41.13000
• Density: 1.265g/cm³
• LogP: 3.77190

Purity/Quality:

99% ^*data from raw suppliers

2-CHLORO-5-METHYL-4-PHENYL-1,3-THIAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-5-METHYL-4-PHENYLTHIAZOLE

There total 1 articles about 2-CHLORO-5-METHYL-4-PHENYLTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 2-chloro-5-methyl-4-phenyl-thiazole (31784-90-4)

Guidance literature:

α-Thiocyanato-propiophenon, HCl/Et2O;

DOI:10.1021/jo01053a059

Reference yield:

2-chloro-5-methyl-4-phenyl-thiazole (31784-90-4) → 5-[1-(4-{2-[Methyl-(5-methyl-4-phenyl-thiazol-2-yl)-amino]-ethoxy}-phenyl)-meth-(Z)-ylidene]-thiazolidine-2,4-dione

Guidance literature:

Multi-step reaction with 3 steps

1: 15 h / 120 °C

2: 1.) NaH / 1.) DMF, RT, 2.) DMF, RT, 18 h

3: piperidinium acetate / toluene / 2 h / Heating

With piperdinium acetate; sodium hydride; In toluene;

DOI:10.1021/jm00049a017

Reference yield:

2-chloro-5-methyl-4-phenyl-thiazole (31784-90-4) → 5-(4-{2-[N-methyl-N-(4-phenyl-5-methylthiazol-2-yl)amino]ethoxy}benzyl)thiazolidine-2,4-dione

Guidance literature:

Multi-step reaction with 4 steps

1: 15 h / 120 °C

2: 1.) NaH / 1.) DMF, RT, 2.) DMF, RT, 18 h

3: piperidinium acetate / toluene / 2 h / Heating

4: 65 percent / Mg, methanol, I₂ / 2 h / Ambient temperature

With methanol; iodine; piperdinium acetate; sodium hydride; magnesium; In toluene;

DOI:10.1021/jm00049a017

Downstream raw materials:

2-methyl-3-phenyl-thiazolo[2,3-b]quinazolin-5-one

2-[Methyl-(5-methyl-4-phenyl-thiazol-2-yl)-amino]-ethanol

4-{2-[Methyl-(5-methyl-4-phenyl-thiazol-2-yl)-amino]-ethoxy}-benzaldehyde

Refernces