Technology Process of Cyclopropanecarboxamide,
N,2,2-trimethyl-3-(2-methyl-1-propenyl)-N-phenyl-, trans-
There total 9 articles about Cyclopropanecarboxamide,
N,2,2-trimethyl-3-(2-methyl-1-propenyl)-N-phenyl-, trans- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1) n-BuLi / 1) THF, 0 deg C, 0.5 h, 2) room temperature, 20 h
2: oxalyl chloride / benzene
3: triethylamine / benzene / 2 h
4: 83 percent / red HgO, BF3*Et2O / H2O; tetrahydrofuran / 0.5 h / Ambient temperature
5: 92 percent / KOH / dioxane / 12 h / Ambient temperature
6: 43 percent / LDA / tetrahydrofuran / 1) -78 deg C, 2) room temperature, 8-12 h
7: 88 percent / CrO3, pyridine / CH2Cl2 / 0.5 h
8: n-BuLi / 1) a) THF, -78 deg C, b) 0 deg C, 0.5 h, 2) room temperature, 4 h
With
pyridine; chromium(VI) oxide; potassium hydroxide; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; triethylamine; mercury(II) oxide; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; benzene;
DOI:10.1021/jo00189a005
- Guidance literature:
-
Multi-step reaction with 7 steps
1: oxalyl chloride / benzene
2: triethylamine / benzene / 2 h
3: 83 percent / red HgO, BF3*Et2O / H2O; tetrahydrofuran / 0.5 h / Ambient temperature
4: 92 percent / KOH / dioxane / 12 h / Ambient temperature
5: 43 percent / LDA / tetrahydrofuran / 1) -78 deg C, 2) room temperature, 8-12 h
6: 88 percent / CrO3, pyridine / CH2Cl2 / 0.5 h
7: n-BuLi / 1) a) THF, -78 deg C, b) 0 deg C, 0.5 h, 2) room temperature, 4 h
With
pyridine; chromium(VI) oxide; potassium hydroxide; n-butyllithium; oxalyl dichloride; boron trifluoride diethyl etherate; triethylamine; mercury(II) oxide; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; benzene;
DOI:10.1021/jo00189a005
- Guidance literature:
-
Multi-step reaction with 6 steps
1: triethylamine / benzene / 2 h
2: 83 percent / red HgO, BF3*Et2O / H2O; tetrahydrofuran / 0.5 h / Ambient temperature
3: 92 percent / KOH / dioxane / 12 h / Ambient temperature
4: 43 percent / LDA / tetrahydrofuran / 1) -78 deg C, 2) room temperature, 8-12 h
5: 88 percent / CrO3, pyridine / CH2Cl2 / 0.5 h
6: n-BuLi / 1) a) THF, -78 deg C, b) 0 deg C, 0.5 h, 2) room temperature, 4 h
With
pyridine; chromium(VI) oxide; potassium hydroxide; n-butyllithium; boron trifluoride diethyl etherate; triethylamine; mercury(II) oxide; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; benzene;
DOI:10.1021/jo00189a005
