ISODEMECOLCINE

Base Information

• Chemical Name: ISODEMECOLCINE
• CAS No.: 4702-33-4
• Molecular Formula: C21H25 N O5
• Molecular Weight: 371.433
• Mol file: 4702-33-4.mol

Synonyms:Benzo[a]heptalen-10(5H)-one,6,7-dihydro-1,2,3,9-tetramethoxy-7-(methylamino)-, (S)-; Isocolchicine,N-deacetyl-N-methyl- (7CI,8CI); Isodemecolcine (6CI)

Chemical Property of ISODEMECOLCINE

Chemical Property:

• PSA: 66.02000
• LogP: 3.34580

Purity/Quality:

98%Min ^*data from raw suppliers

Isodemecolcine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Technology Process of ISODEMECOLCINE

There total 7 articles about ISODEMECOLCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + demecolceine (518-11-6,14917-53-4) → isodemecolcine (4702-33-4) + (-)-demecolcine (477-30-5)

Guidance literature:

With diethyl ether; chloroform;

DOI:10.1002/hlca.19540370104

Reference yield:

colchicine (64-86-8,54192-66-4) → isodemecolcine (4702-33-4)

Guidance literature:

Multi-step reaction with 5 steps

1: aqueous HCl

2: CH₂Cl₂; diethyl ether

3: benzene

4: aqueous HCl

5: CHCl₃; diethyl ether

With hydrogenchloride; diethyl ether; dichloromethane; chloroform; benzene;

DOI:10.1002/hlca.19540370104

Reference yield:

deacetylcolchicine (3476-50-4) → isodemecolcine (4702-33-4)

Guidance literature:

Multi-step reaction with 3 steps

1: benzene

2: aqueous HCl

3: CHCl₃; diethyl ether

With hydrogenchloride; diethyl ether; chloroform; benzene;

DOI:10.1002/hlca.19540370104

upstream raw materials:

diazomethane

demecolceine

colchicine

deacetylcolchicine

Downstream raw materials:

N-acetylisodemecolcine