homoproline

Base Information

• Chemical Name: homoproline
• CAS No.: 56879-46-0
• Molecular Formula: C6H11 N O2
• Molecular Weight: 129.159
• Hs Code.: 2933990090

Synonyms:(?à)-Homoproline

Chemical Property of homoproline

Chemical Property:

• Vapor Pressure: 0.0017mmHg at 25°C
• Melting Point: 145-148 °C
• Boiling Point: 272.3°C at 760 mmHg
• PKA: 4.00±0.10(Predicted)
• Flash Point: 118.5°C
• PSA: 49.33000
• Density: 1.104g/cm³
• LogP: 0.54190
• Storage Temp.: 2-8°C
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

(+/-)-Homoproline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It was isolated from Melampodium divaricatum; a new GABA-uptake inhibitor derived from proline.

Technology Process of homoproline

There total 4 articles about homoproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

malonic acid (141-82-2) + dodecahydro-3a,6a,9a-triaza-trindene (5981-17-9,64314-29-0) → 2-(pyrrolidin-2-yl)acetic acid (56879-46-0)

Guidance literature:

With triethylamine; In acetonitrile; at 55 - 60 ℃; for 2.5h;

DOI:10.1246/cl.1982.231

Reference yield:

→ 2-(pyrrolidin-2-yl)acetic acid (56879-46-0)

Guidance literature:

With chromium(VI) oxide; sulfuric acid;

DOI:10.1021/jo01135a015

Reference yield:

2-carboxymethyl-pyrrolidine-1-carboxylic acid methyl ester → 2-(pyrrolidin-2-yl)acetic acid (56879-46-0)

Guidance literature:

With hydrogen bromide; acetic acid; at 20 ℃; for 16h;

DOI:10.1016/j.tetasy.2004.09.022

upstream raw materials:

malonic acid

dodecahydro-3a,6a,9a-triaza-trindene

Downstream raw materials:

2-methoxycarbonylmethylpyrrolidine-1-carboxylic acid tert-butyl ester

C₂₉H₄₃N₆O₃S⁽¹⁺⁾*C₅H₁₀NO₄S^(1-)

N-Boc-prolinol

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