2,3-Piperazinedione, 1-phenyl-4-(p-(2-pyrimidinylamino)benzyl)-

Base Information

Chemical Name:2,3-Piperazinedione, 1-phenyl-4-(p-(2-pyrimidinylamino)benzyl)-
CAS No.:77916-98-4
Molecular Formula:C21H19N5O2
Molecular Weight:373.414
Hs Code.:
DSSTox Substance ID:DTXSID80228548
Nikkaji Number:J117.831H
Wikidata:Q83108540

Synonyms:BRN 5642749;2,3-Piperazinedione, 1-phenyl-4-(p-(2-pyrimidinylamino)benzyl)-;1-Phenyl-4-(p-(2-pyrimidinylamino)benzyl)-2,3-piperazinedione;77916-98-4;SCHEMBL11044711;DTXSID80228548;LS-111908;1-Phenyl-4-[4-(2-pyrimidinylamino)benzyl]-2,3-piperazinedione

Suppliers and Price of 2,3-Piperazinedione, 1-phenyl-4-(p-(2-pyrimidinylamino)benzyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2,3-Piperazinedione, 1-phenyl-4-(p-(2-pyrimidinylamino)benzyl)-

Chemical Property:

Vapor Pressure:8.81E-14mmHg at 25°C
Boiling Point:587.5°C at 760 mmHg
Flash Point:309.1°C
Density:1.35g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:373.15387487
Heavy Atom Count:28
Complexity:537

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(C(=O)C(=O)N1CC2=CC=C(C=C2)NC3=NC=CC=N3)C4=CC=CC=C4

Technology Process of 2,3-Piperazinedione, 1-phenyl-4-(p-(2-pyrimidinylamino)benzyl)-

There total 3 articles about 2,3-Piperazinedione, 1-phenyl-4-(p-(2-pyrimidinylamino)benzyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 591-50-4
iodobenzene

: 77916-96-2
1-<4-(2-pyrimidinylamino)benzyl>-2,3-dioxopiperazine

: 77916-98-4
1-phenyl-4-<4-(2-pyrimidinylamino)benzyl>-2,3-dioxopiperazine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 77916-86-0
1-(4-aminobenzyl)-2,3-dioxopiperazine

: 77916-98-4
1-phenyl-4-<4-(2-pyrimidinylamino)benzyl>-2,3-dioxopiperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 68.8 percent / dimethylformamide / 0.5 h / 130 - 140 °C

2: K₂CO₃, activated Cu / dimethylformamide / 4 h / Heating

With copper; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.1253

Reference yield:

: 78789-06-7
1-(4-nitrobenzyl)-2,3-dioxopiperazine

: 77916-98-4
1-phenyl-4-<4-(2-pyrimidinylamino)benzyl>-2,3-dioxopiperazine

Guidance literature:: Multi-step reaction with 3 steps

1: Zn-CaCl₂ / H₂O; ethanol

2: 68.8 percent / dimethylformamide / 0.5 h / 130 - 140 °C

3: K₂CO₃, activated Cu / dimethylformamide / 4 h / Heating

With copper; potassium carbonate; calcium chloride; zinc; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.1253