Technology Process of 3-Butenoic acid, 2-(hydroxyimino)-3-(hydroxymethyl)-, diphenylmethyl
ester
There total 6 articles about 3-Butenoic acid, 2-(hydroxyimino)-3-(hydroxymethyl)-, diphenylmethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: H(OEt)3 / n-Bu4N(1+)*Br(1-) / ethyl acetate; H2O / 50 °C
2: HCl / ethanol; ethyl acetate
3: 70 percent / NaNO2 / aq. acetic acid / 0 °C
4: 1.) p-TsOH, pyridine, 2.) Et3N, CH2Cl2
5: 65 percent / n-BuLi, hexamethyl phosphoramide / diethyl ether / 5 - 10 °C
6: HCl / methanol / Ambient temperature
With
pyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; dichloromethane; H(OEt)3; toluene-4-sulfonic acid; triethylamine; sodium nitrite;
tetrabutylammomium bromide;
In
methanol; diethyl ether; ethanol; water; acetic acid; ethyl acetate;
DOI:10.1016/S0040-4039(01)81489-1
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 70 percent / NaNO2 / aq. acetic acid / 0 °C
2: 1.) p-TsOH, pyridine, 2.) Et3N, CH2Cl2
3: 65 percent / n-BuLi, hexamethyl phosphoramide / diethyl ether / 5 - 10 °C
4: HCl / methanol / Ambient temperature
With
pyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; dichloromethane; toluene-4-sulfonic acid; triethylamine; sodium nitrite;
In
methanol; diethyl ether; acetic acid;
DOI:10.1016/S0040-4039(01)81489-1
