4-Chloronaphthalen-2-amine

Base Information

• Chemical Name: 4-Chloronaphthalen-2-amine
• CAS No.: 90799-46-5
• Molecular Formula: C10H8ClN
• Molecular Weight: 177.63000
• DSSTox Substance ID: DTXSID80541446
• Wikidata: Q82417814
• Mol file: 90799-46-5.mol

Synonyms:4-Chloronaphthalen-2-amine;90799-46-5;SCHEMBL11715187;DTXSID80541446;CS-0433552

Chemical Property of 4-Chloronaphthalen-2-amine

Chemical Property:

• PSA: 26.02000
• LogP: 3.65660
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 177.0345270
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-4-chloronaphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=C(C=C2Cl)N

Technology Process of 4-Chloronaphthalen-2-amine

There total 6 articles about 4-Chloronaphthalen-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloro-3-nitronaphthalene (53526-29-7) → 4-chloro-2-naphthylamine (90799-46-5)

Guidance literature:

With ethanol; platinum; Hydrogenation;

DOI:10.1021/jo01368a011

Reference yield:

3-nitro-1-naphthalenamine (3229-86-5) → 4-chloro-2-naphthylamine (90799-46-5)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) H₂SO₄, (ii) aq. NaNO₂, (iii) CuCl, aq. HCl

2: Fe, aq. HCl / ethanol / Heating

With hydrogenchloride; iron; In ethanol;

DOI:10.1021/jm00257a016

Reference yield:

N-(2-nitronaphthalen-1-yl)acetamide (2437-30-1) → 4-chloro-2-naphthylamine (90799-46-5)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid; chlorine

2: aqueous ethanolic sulfuric acid

3: concentrated H₂SO₄; glacial acetic acid / Diazotization_.Erwaermen der Diazoniumsalz-Loesung mit Aethanol

4: tin (II)-chloride; aq.-ethanolic hydrochloric acid

With hydrogenchloride; sulfuric acid; chlorine; acetic acid; tin(ll) chloride;

DOI:10.1039/jr9350001850

upstream raw materials:

1-chloro-3-nitronaphthalene

N-(2-nitronaphthalen-1-yl)acetamide

4-chloro-2-nitro-1-naphthylamine

N-(4-chloro-2-nitro-[1]naphthyl)-acetamide

Downstream raw materials:

3-bromo-1-chloronaphthalene

Refernces