N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid

Base Information

Chemical Name:N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid
CAS No.:142434-84-2
Molecular Formula:C₂₆H₃₄N₄O₁₀S
Molecular Weight:594.643
Hs Code.:
Mol file:142434-84-2.mol

Synonyms:Glycine,N-[2-[bis(carboxymethyl)amino]cyclohexyl]-N-[2-[bis(carboxymethyl)amino]-3-(4-isothiocyanatophenyl)propyl]-,[1a(S*),2b]-(?à)-; CHX-A-DTPA

Suppliers and Price of N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid

Chemical Property:

Boiling Point:905.3°Cat760mmHg
Flash Point:501.3°C
PSA：0.00000
Density:1.44g/cm³
LogP:0.00000

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid

There total 24 articles about N-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-N,N',N',N'',N''-pentaacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 463-71-8
thiophosgene

: 133725-78-7,133775-66-3,137174-09-5,142434-88-6,142434-89-7,1105741-38-5
N-<2-amino-3-(p-aminophenyl)propyl>-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid

: 133725-79-8,133775-67-4,137174-07-3,142434-84-2,142434-85-3,157380-45-5
N-<2-amino-3-(p-isothiocyanatophenyl)propyl>-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid

Guidance literature:: In chloroform; water; for 2h;
DOI:10.1039/P19920001173

Reference yield: 92.0%

: 463-71-8
thiophosgene

: 133725-78-7,133775-66-3,137174-09-5,142434-88-6,142434-89-7,1105741-38-5
N-<2-amino-3-(p-aminophenyl)propyl>-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid

: 133725-79-8,133775-67-4,137174-07-3,142434-84-2,142434-85-3,157380-45-5
N-<2-amino-3-(p-isothiocyanatophenyl)propyl>-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid

Guidance literature:: In chloroform; water; for 2h;
DOI:10.1039/P19920001173

Reference yield:

: 88319-56-6
N-tert-butoxycarbonyl-p-nitrophenylalanine N-hydroxysuccinimidyl ester

: 133725-79-8,133775-67-4,137174-07-3,142434-84-2,142434-85-3,157380-45-5
N-<2-amino-3-(p-isothiocyanatophenyl)propyl>-trans-cyclohexane-1,2-diamine-N,N',N'N'',N''-penta-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: dimethylformamide

2: HCl(g) / dioxane / 1) 8 h, 2) 4 deg C, 12 h

3: 1) BH₃, 2) HCl(g) / 1) THF, 50 deg C, 48 h, 2a) dioxane, reflux, 5 h, b) r. t., 12 h

4: 1) Na₂CO₃ / 1) DMF, 65 deg C, 2) DMF, 90 deg C, 12 h

5: CF₃CO₂H / 12 h

6: 96 percent / H₂ / 10percent Pd-C / H₂O / 760 Torr

7: 94 percent / H₂O; CHCl₃ / 2 h

With hydrogenchloride; borane; hydrogen; sodium carbonate; trifluoroacetic acid; palladium on activated charcoal; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1039/P19920001173