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Technology Process of Azaspiracid1

Azaspiracid1

Base Information
  • Chemical Name:Azaspiracid1
  • CAS No.:214899-21-5
  • Molecular Formula:C47H71NO12
  • Molecular Weight: 842.08
  • Hs Code.:
  • DSSTox Substance ID:DTXSID9040974
  • Metabolomics Workbench ID:181383
  • Nikkaji Number:J2.290.668B
Azaspiracid1

Synonyms:AZASPIRACID1;Azaspiracid 1;DTXSID9040974

Suppliers and Price of Azaspiracid1
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • American Custom Chemicals Corporation
  • AZASPIRACID-1 95.00%
  • 5MG
  • $ 497.56
Total 27 raw suppliers
Chemical Property of Azaspiracid1
Chemical Property:
  • Boiling Point:°Cat760mmHg 
  • Flash Point:°C 
  • Density:1.27g/cm3 
  • XLogP3:3.9
  • Hydrogen Bond Donor Count:4
  • Hydrogen Bond Acceptor Count:13
  • Rotatable Bond Count:9
  • Exact Mass:841.49762670
  • Heavy Atom Count:60
  • Complexity:1690
Purity/Quality:

98%Min *data from raw suppliers

AZASPIRACID-1 95.00% *data from reagent suppliers

Safty Information:
  • Pictogram(s): A poison by ingestion. 
  • Hazard Codes:A poison by ingestion. 
MSDS Files:
Useful:
  • Canonical SMILES:CC1CC2C3C(CC4(O3)C(CC(CN4)C)C)OC(C1)(O2)CC(=C)C5C(CC(C(O5)(C(C6CC7C(O6)CC(C8(O7)CCC9(O8)CC=CC(O9)C=CCCC(=O)O)C)O)O)C)C
  • Isomeric SMILES:C[C@H]1C[C@@H]2[C@@H]3[C@@H](C[C@]4(O3)[C@H](C[C@H](CN4)C)C)O[C@](C1)(O2)CC(=C)[C@@H]5[C@H](C[C@H]([C@@](O5)([C@@H]([C@@H]6C[C@@H]7[C@H](O6)C[C@H]([C@@]8(O7)CC[C@@]9(O8)CC=C[C@H](O9)/C=C/CCC(=O)O)C)O)O)C)C
Technology Process of Azaspiracid1

There total 59 articles about Azaspiracid1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C<sub>47</sub>H<sub>71</sub>NO<sub>11</sub>

C47H71NO11

(+)-azaspiracid
214899-21-5

(+)-azaspiracid

Guidance literature:
With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In tert-butyl alcohol;
DOI:10.1002/anie.200701520

Reference yield: 60.0%

C<sub>65</sub>H<sub>111</sub>NO<sub>14</sub>Si<sub>3</sub>
782479-30-5

C65H111NO14Si3

azaspiracid-1
214899-21-5

azaspiracid-1

Guidance literature:
With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 15h;
DOI:10.1002/anie.200460696

Reference yield: 55.0%

C<sub>65</sub>H<sub>111</sub>NO<sub>14</sub>Si<sub>3</sub>
881652-02-4

C65H111NO14Si3

C1-C20-epimerof azaspiracid-1
214899-21-5

C1-C20-epimerof azaspiracid-1

Guidance literature:
With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 15h;
DOI:10.1021/ja054750q
upstream raw materials:

C65H111NO14Si3

C26H38O7

C26H40O7

C26H38O8

Refernces

Synthesis of the azaspiracid-1 trioxadispiroketal

10.1021/ol048581a

The study focuses on the de novo analysis, design, and synthesis of the azaspiracid-1 trioxadispiroketal system, a complex natural product with significant human health implications. The researchers developed a revised structural model based on an independent analysis of NMR spectral data and thermodynamic considerations. They tested this model through synthesis using a novel trioxadispiroketalization process. Key chemicals used in the study include THFynedione, TES ethers, Gilman reagents, and organochromium mediators, which served to construct and modify the complex molecular structure of the azaspiracid-1. The purpose of these chemicals was to facilitate the synthesis of the target compound, with specific roles in ring formation, stereochemistry control, and functional group transformations, ultimately aiming to provide an intermediate applicable to a concise total synthesis of the azaspiracids.

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