(Diphenylmethyl)(2,4,6-trimethylphenyl)phosphinic chloride

Base Information

• Chemical Name: (Diphenylmethyl)(2,4,6-trimethylphenyl)phosphinic chloride
• CAS No.: 90929-02-5
• Molecular Formula: C₂₂H₂₂ClOP
• Molecular Weight: 368.843
• DSSTox Substance ID: DTXSID90532340
• Mol file: 90929-02-5.mol

Synonyms:90929-02-5;(Diphenylmethyl)(2,4,6-trimethylphenyl)phosphinic chloride;DTXSID90532340

Chemical Property of (Diphenylmethyl)(2,4,6-trimethylphenyl)phosphinic chloride

Chemical Property:

• XLogP3: 6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 368.1096800
• Heavy Atom Count: 25
• Complexity: 437

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C(C(=C1)C)P(=O)(C(C2=CC=CC=C2)C3=CC=CC=C3)Cl)C

Technology Process of (Diphenylmethyl)(2,4,6-trimethylphenyl)phosphinic chloride

There total 5 articles about (Diphenylmethyl)(2,4,6-trimethylphenyl)phosphinic chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,6-trimethylphenyl bromide (576-83-0) → C22H22ClOP (90929-02-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) Mg / 1.) THF, 2.) THF, -40 deg C to -50 deg C, 1.5h

2: 49 percent / 1.68N HCl / diethyl ether

3: 1.) 1.5N n-butyllithium / 1.) THF, hexane, 2.) 20h, RT

4: 73 percent Spectr_. / 2.14N HCl / tetrahydrofuran; diethyl ether

5: H₂O₂ / acetone

With hydrogenchloride; n-butyllithium; dihydrogen peroxide; magnesium; In tetrahydrofuran; diethyl ether; acetone;

DOI:10.1016/S0040-4020(01)91106-8

Reference yield:

PCl(mesityl)CHPh2 (67565-90-6) → C22H22ClOP (90929-02-5)

Guidance literature:

With dihydrogen peroxide; In acetone;

DOI:10.1016/S0040-4020(01)91106-8

Reference yield:

diethylaminochloro-2,4,6-trimethylphenylphosphine (90928-95-3) → C22H22ClOP (90929-02-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 1.5N n-butyllithium / 1.) THF, hexane, 2.) 20h, RT

2: 73 percent Spectr_. / 2.14N HCl / tetrahydrofuran; diethyl ether

3: H₂O₂ / acetone

With hydrogenchloride; n-butyllithium; dihydrogen peroxide; In tetrahydrofuran; diethyl ether; acetone;

DOI:10.1016/S0040-4020(01)91106-8

upstream raw materials:

PCl(mesityl)CHPh₂

2,4,6-trimethylphenyl bromide

diethylaminochloro-2,4,6-trimethylphenylphosphine

bis(diethylamino)-2,4,6-trimethylphenylphosphine