Chloromethyl(p-nitrophenyl) sulfone

Base Information

• Chemical Name: Chloromethyl(p-nitrophenyl) sulfone
• CAS No.: 7239-20-5
• Molecular Formula: C12H28O4P2PtS4+2
• Molecular Weight: 621.6387
• Mol file: 7239-20-5.mol

Synonyms:(p-Nitrophenylsulfonyl)-chlormethan;Benzene,1-chloro-2-(chloromethoxy);1-Chloro-2-chloromethoxybenzene;chloromethyl 2-chlorophenyl ether;Chlormethyl-(2-chlor-phenyl)-aether;Chlormethyl-(4-nitrophenyl)-sulfon;Chlormethyl-p-nitrophenyl-sulfon;

Chemical Property of Chloromethyl(p-nitrophenyl) sulfone

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 120.72000
• Density: g/cm³
• LogP: 6.51430

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Chloromethyl(p-nitrophenyl) sulfone

There total 5 articles about Chloromethyl(p-nitrophenyl) sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-methylthio-4-nitro-benzene (701-57-5) → chloromethyl 4-nitrophenyl sulfone (7239-20-5)

Guidance literature:

1-methylthio-4-nitro-benzene; With N-iodo-succinimide; In tetrachloromethane; at 35 ℃; for 24h;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 5.66667h;

DOI:10.1021/acs.joc.6b02844

Reference yield:

1-((diazomethyl)sulfonyl)-4-nitrobenzene (1538-94-9) → chloromethyl 4-nitrophenyl sulfone (7239-20-5)

Guidance literature:

With hydrogenchloride; In diethyl ether;

Reference yield:

N-(p-Nitro-phenylsulfonylmethyl)-urethan (90870-57-8) → chloromethyl 4-nitrophenyl sulfone (7239-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NOCl, Py

2: diethyl ether

3: HCl / diethyl ether

With pyridine; hydrogenchloride; nitrosylchloride; In diethyl ether;

upstream raw materials:

1-((diazomethyl)sulfonyl)-4-nitrobenzene

N-(p-Nitro-phenylsulfonylmethyl)-urethan

N-(p-Nitrophenylsulfonylmethyl)-N-nitroso-urethan

1-methylthio-4-nitro-benzene