2-(piperidin-1-yl)quinoline

Base Information

• Chemical Name: 2-(piperidin-1-yl)quinoline
• CAS No.: 46708-03-6
• Molecular Formula: C₁₄H₁₆N₂
• Molecular Weight: 212.294
• Mol file: 46708-03-6.mol

Synonyms:Quinoline,2-piperidino- (5CI); NSC 246055

Chemical Property of 2-(piperidin-1-yl)quinoline

Chemical Property:

• Vapor Pressure: 9.4E-06mmHg at 25°C
• Boiling Point: 372.8°Cat760mmHg
• Flash Point: 179.2°C
• Density: 1.122g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(piperidin-1-yl)quinoline

There total 11 articles about 2-(piperidin-1-yl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(piperidin-1-yl)quinoline-N-oxide (10286-46-1) → 2-(piperidin-1-yl)quinoline (46708-03-6)

Guidance literature:

With phosphorus trichloride; In toluene; at 25 ℃; for 1h;

DOI:10.1016/j.tetlet.2021.153415

Reference yield: 88.0%

piperidine (110-89-4) + 2-Chloroquinoline (612-62-4) → 2-(piperidin-1-yl)quinoline (46708-03-6)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; potassium carbonate; cobalt(II) chloride; In para-xylene; at 135 ℃; for 3h; Inert atmosphere;

DOI:10.1002/ejoc.200900597

Reference yield: 86.0%

piperidine (110-89-4) + 2-methoxy-quinoline (6931-16-4) → 2-(piperidin-1-yl)quinoline (46708-03-6)

Guidance literature:

With sodium hydride; lithium iodide; In tetrahydrofuran; at 0 - 60 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1039/C8CC05979A

upstream raw materials:

piperidine

2-Chloroquinoline

N-formyldiethylamine

Acetanilid

Refernces

• 1、 Sahoo, Tapan,Thakur, Dinesh,Panda, Asit Baran,Ghosh, Subhash Chandra. "Copper/manganese oxide catalyzed regioselective amination of quinoline N-oxides: An example of synergistic cooperative catalysis". . . Retrieved 2021/09/29.
• 2、 -. "2-alkylamine quinoline compound for preventing and treating candida albicans as well as preparation method and application of 2-alkylamine quinoline compound". Paragraph 0017; 0028; 0029; 0030; 0031. . Retrieved 2018/08/04.