Methyl 3-(2-amino-4-chlorophenoxy)-2-thiophenecarboxylate

Base Information

Chemical Name:Methyl 3-(2-amino-4-chlorophenoxy)-2-thiophenecarboxylate
CAS No.:91041-14-4
Molecular Formula:C12H10ClNO3S
Molecular Weight:283.735
Hs Code.:
DSSTox Substance ID:DTXSID501197356

Synonyms:Oprea1_523476;DTXSID501197356;Methyl 3-(2-amino-4-chlorophenoxy)-2-thiophenecarboxylate;91041-14-4

Suppliers and Price of Methyl 3-(2-amino-4-chlorophenoxy)-2-thiophenecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3-(2-amino-4-chlorophenoxy)-2-thiophenecarboxylate

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:283.0069920
Heavy Atom Count:18
Complexity:305

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=C(C=CS1)OC2=C(C=C(C=C2)Cl)N

Technology Process of Methyl 3-(2-amino-4-chlorophenoxy)-2-thiophenecarboxylate

There total 2 articles about Methyl 3-(2-amino-4-chlorophenoxy)-2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 91041-13-3
3-(4-Chloro-2-nitro-phenoxy)-thiophene-2-carboxylic acid methyl ester

: 91041-14-4
3-(2-Amino-4-chloro-phenoxy)-thiophene-2-carboxylic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; under 3102.9 Torr;
DOI:10.1002/jhet.5570220542

Reference yield:

: 89-61-2
2,5-dichloronitrobenzene

: 91041-14-4
3-(2-Amino-4-chloro-phenoxy)-thiophene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / potassium carbonate / dimethylsulfoxide / 20 h / 100 °C

2: 94 percent / hydrogen / palladium on charcoal (10percent) / methanol / 3102.9 Torr

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; dimethyl sulfoxide;
DOI:10.1002/jhet.5570220542