Streptomycin sulfate

Base Information

• Chemical Name: Streptomycin sulfate
• CAS No.: 3810-74-0
• Deprecated CAS: 15105-93-8,298-39-5,67479-32-7,8018-05-1,85027-84-5,82115-93-3,298-39-5,67479-32-7,8018-05-1,82115-93-3,85027-84-5
• Molecular Formula: C42H84N14O36S3
• Molecular Weight: 1457.4
• Hs Code.: 3004.10
• European Community (EC) Number: 223-286-0
• UNII: CW25IKJ202
• DSSTox Substance ID: DTXSID9026053
• Wikidata: Q27275850
• NCI Thesaurus Code: C47729
• RXCUI: 10110
• ChEMBL ID: CHEMBL3184791
• Mol file: 3810-74-0.mol

Synonyms:Estreptomicina CEPA;Estreptomicina Clariana;Estreptomicina Normon;Strepto Fatol;Strepto Hefa;Strepto-Fatol;Strepto-Hefa;Streptomycin;Streptomycin Grünenthal;Streptomycin Sulfate;Streptomycin Sulfate (2:3) Salt;Streptomycin Sulphate;Streptomycine Panpharma

Chemical Property of Streptomycin sulfate

Chemical Property:

• Appearance/Colour: White to off-white powder
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: -85 ° (C=1, H2O)
• Boiling Point: 948.2 °C at 760 mmHg
• Flash Point: 527.3 °C
• PSA: 911.80000
• Density: 1.2302 (rough estimate)
• LogP: -8.65400
• Storage Temp.: 2-8°C
• Solubility.: H2O: 0.1 g/mL, clear
• Water Solubility.: >=0.01 g/100 mL at 18 ºC
• Hydrogen Bond Donor Count: 30
• Hydrogen Bond Acceptor Count: 42
• Rotatable Bond Count: 18
• Exact Mass: 1456.4334786
• Heavy Atom Count: 95
• Complexity: 1020

Purity/Quality:

99%, ^*data from raw suppliers

Streptomycin Sulfate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-63-42/43
• Safety Statements: 26-36-36/37-45-22-60

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O.CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O
• Isomeric SMILES: C[C@H]1[C@@]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H]([C@@H]([C@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC)(C=O)O.C[C@H]1[C@@]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H]([C@@H]([C@H]2O)O)N=C(N)N)O)N=C(N)N)O[C@H]3[C@H]([C@@H]([C@H]([C@@H](O3)CO)O)O)NC)(C=O)O.OS(=O)(=O)O.OS(=O)(=O)O.OS(=O)(=O)O
• Recent ClinicalTrials: A Prospective Study of Multidrug Resistance and a Pilot Study of the Safety of and Clinical and Microbiologic Response to Levofloxacin in Combination With Other Antimycobacterial Drugs for Treatment of Multidrug-Resistant Pulmonary Tuberculosis (MDRTB) in HIV-Infected Patients.
• Drug Interactions: 1. Combination of Streptomycin and penicillin or cephalosporins has synergistic effect. 2. its antibacterial activity can be enhanced in alkaline environment, and being used in combination with basic drugs (such as sodium bicarbonate) can further enhance the antimicrobial potency. 3. Cations such as Ca2 +, Mg2 +, Na+, NH4+, K+ inhibit the antibacterial activity of the product. 4. Combination of streptomycin sulfate with cephalosporins, erythromycin can enhance the ototoxicity of this class of drugs. The above information is edited by the lookchem of Dai Xiongfeng.
• Uses: It is used for treating tuberculosis, Brinell and non-hemolytic hammer bacillus caused infectious endocarditis, plague and tularemia, Haemophilus influenzae and gram-negative bacilli caused infections. Antibiotic substance produced by aerobic fermentation. Antibacterial (tuberculostatic). Streptomycin sulfate is a sulfate salt of streptomycin that is a protein synthesis inhibitor. Streptomycin is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis. Triacetine
• Clinical Use: Streptomycin sulfate is a white, odorless powder that is hygroscopicbut stable toward light and air. It is freely solublein water, forming solutions that are slightly acidic or nearlyneutral. It is very slightly soluble in alcohol and is insolublein most other organic solvents. Acid hydrolysis yields streptidineand streptobiosamine, the compound that is a combinationof L-streptose and N-methyl-L-glucosamine.Streptomycin acts as a triacidic base through the effectof its two strongly basic guanidino groups and the moreweakly basic methylamino group. Aqueous solutions maybe stored at room temperature for 1 week without any lossof potency, but they are most stable if the pH is between 4.5and 7.0. The solutions decompose if sterilized by heating,so sterile solutions are prepared by adding sterile distilledwater to the sterile powder. The early salts of streptomycincontained impurities that were difficult to remove andcaused a histamine-like reaction. By forming a complexwith calcium chloride, it was possible to free the streptomycinfrom these impurities and to obtain a product thatwas generally well tolerated.The organism that produces streptomycin, S. griseus, alsoproduces several other antibiotic compounds: hydroxystreptomycin,mannisidostreptomycin, and cycloheximide (q.v.).Of these, only cycloheximide has achieved importance as amedicinally useful substance. The term streptomycin A hasbeen used to refer to what is commonly called streptomycin,and mannisidostreptomycin has been called streptomycin B.Hydroxystreptomycin differs from streptomycin in having ahydroxyl group in place of one of the hydrogen atoms of thestreptose methyl group. Mannisidostreptomycin has a mannoseresidue attached in glycosidic linkage through the hydroxylgroup at C-4 of the N-methyl-L-glucosamine moiety.The work of Dyer et al. to establish the stereochemicalstructure of streptomycin has been completed, and confirmedwith the total synthesis of streptomycin and dihydrostreptomycinby Japanese scientists.