1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 6-chloro-1-[4-(1,1-dimethylethyl)phenyl]-3-[[4-(trifluoromethyl)-2-pyridinyl ]oxy]-, ethyl ester

Base Information

Chemical Name:1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 6-chloro-1-[4-(1,1-dimethylethyl)phenyl]-3-[[4-(trifluoromethyl)-2-pyridinyl ]oxy]-, ethyl ester
CAS No.:911846-66-7
Molecular Formula:C26H23ClF3N3O3
Molecular Weight:517.935
Hs Code.:

1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid,
6-chloro-1-[4-(1,1-dimethylethyl)phenyl]-3-[[4-(trifluoromethyl)-2-pyridinyl
]oxy]-, ethyl ester

Synonyms:

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Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 6-chloro-1-[4-(1,1-dimethylethyl)phenyl]-3-[[4-(trifluoromethyl)-2-pyridinyl ]oxy]-, ethyl ester

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Technology Process of 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 6-chloro-1-[4-(1,1-dimethylethyl)phenyl]-3-[[4-(trifluoromethyl)-2-pyridinyl ]oxy]-, ethyl ester

There total 5 articles about 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 6-chloro-1-[4-(1,1-dimethylethyl)phenyl]-3-[[4-(trifluoromethyl)-2-pyridinyl ]oxy]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870459-90-8
4-(trifluoromethyl)-2-pyridinylboronic acid

: 911842-77-8
1-(4-tert-butyl-phenyl)-6-chloro-3-hydroxy-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester

: 911846-66-7
1-(4-tert-butyl-phenyl)-6-chloro-3-(4-trifluoromethyl-pyridin-2-yloxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester

Guidance literature:: With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2005.08.002

Reference yield:

: 870459-83-9
ethyl 2-((4-(tert-butyl)phenyl)amino)acetate

: 911846-66-7
1-(4-tert-butyl-phenyl)-6-chloro-3-(4-trifluoromethyl-pyridin-2-yloxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / 6 h / 130 °C

2: 40 percent / NaOEt / ethanol; diethyl ether / 2 h / Heating

3: Cu(OAc)2; Et₃N / CH₂Cl₂ / 16 h / 20 °C

With copper diacetate; sodium ethanolate; triethylamine; In diethyl ether; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.08.002

Reference yield:

: 911842-18-7
2-[(4-tert-butyl-phenyl)-ethoxycarbonylmethyl-amino]-6-chloro-nicotinic acid ethyl ester

: 911846-66-7
1-(4-tert-butyl-phenyl)-6-chloro-3-(4-trifluoromethyl-pyridin-2-yloxy)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / NaOEt / ethanol; diethyl ether / 2 h / Heating

2: Cu(OAc)2; Et₃N / CH₂Cl₂ / 16 h / 20 °C

With copper diacetate; sodium ethanolate; triethylamine; In diethyl ether; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2005.08.002