3-Methyl-5-(2-oxopropyl)dihydrofuran-2(3h)-one

Base Information

Chemical Name:3-Methyl-5-(2-oxopropyl)dihydrofuran-2(3h)-one
CAS No.:90482-36-3
Molecular Formula:C₈H₁₂O₃
Molecular Weight:156.181
Hs Code.:
NSC Number:135355
DSSTox Substance ID:DTXSID70300201
Wikidata:Q82043074

Synonyms:90482-36-3;3-methyl-5-(2-oxopropyl)dihydrofuran-2(3h)-one;NSC135355;DTXSID70300201;AKOS024328976;NSC-135355;3-METHYL-5-(2-OXOPROPYL)DIHYDRO-2(3H)-FURANONE

Suppliers and Price of 3-Methyl-5-(2-oxopropyl)dihydrofuran-2(3h)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 3-Methyl-5-(2-oxopropyl)dihydrofuran-2(3h)-one

Chemical Property:

Vapor Pressure:0.00179mmHg at 25°C
Boiling Point:292.9°Cat760mmHg
Flash Point:129.2°C
Density:1.059g/cm³
XLogP3:0.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:156.078644241
Heavy Atom Count:11
Complexity:186

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CC(OC1=O)CC(=O)C

Technology Process of 3-Methyl-5-(2-oxopropyl)dihydrofuran-2(3h)-one

There total 11 articles about 3-Methyl-5-(2-oxopropyl)dihydrofuran-2(3h)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₅NO₃

: 90482-36-3
(3S)-methyl-5-(2-oxopropyl)dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C

2.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 - 0 °C / Inert atmosphere

4.1: triethylamine; dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

7.1: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 1 h / 20 °C / Inert atmosphere

8.1: (1-(4-((triethylammonium chloride)methyl)benzyl)-3-mesityl-2,3-dihydro-1H-imidazol-2-yl)gold(I)chloride / tetrahydrofuran / 2 h

9.1: hydrogen; palladium on activated charcoal / methanol / 20 °C

10.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / Inert atmosphere

With 1H-imidazole; dmap; sodium chlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; n-butyllithium; palladium on activated charcoal; (1-(4-((triethylammonium chloride)methyl)benzyl)-3-mesityl-2,3-dihydro-1H-imidazol-2-yl)gold(I)chloride; tetrabutyl ammonium fluoride; hydrogen; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1039/c5ob01286d

Reference yield:

: 58113-69-2,107691-93-0
(2S)-2-methyl-4-pentyn-1-ol

: 90482-36-3
(3S)-methyl-5-(2-oxopropyl)dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 0 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 0 °C / Inert atmosphere

3.1: triethylamine; dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

6.1: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 1 h / 20 °C / Inert atmosphere

7.1: (1-(4-((triethylammonium chloride)methyl)benzyl)-3-mesityl-2,3-dihydro-1H-imidazol-2-yl)gold(I)chloride / tetrahydrofuran / 2 h

8.1: hydrogen; palladium on activated charcoal / methanol / 20 °C

9.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / Inert atmosphere

With 1H-imidazole; dmap; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; palladium on activated charcoal; (1-(4-((triethylammonium chloride)methyl)benzyl)-3-mesityl-2,3-dihydro-1H-imidazol-2-yl)gold(I)chloride; tetrabutyl ammonium fluoride; hydrogen; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1039/c5ob01286d

Reference yield:

: 125643-08-5
(4R)-5-<(tert-Butyldimethylsilyl)oxy>-4-methyl-1-pentyne

: 90482-36-3
(3S)-methyl-5-(2-oxopropyl)dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 0 °C / Inert atmosphere

2.1: triethylamine; dmap / dichloromethane / 3 h / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 3 h / 20 °C / Inert atmosphere

5.1: sodium chlorite; sodium dihydrogenphosphate / water; tert-butyl alcohol / 1 h / 20 °C / Inert atmosphere

6.1: (1-(4-((triethylammonium chloride)methyl)benzyl)-3-mesityl-2,3-dihydro-1H-imidazol-2-yl)gold(I)chloride / tetrahydrofuran / 2 h

7.1: hydrogen; palladium on activated charcoal / methanol / 20 °C

8.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / Inert atmosphere

With dmap; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; palladium on activated charcoal; (1-(4-((triethylammonium chloride)methyl)benzyl)-3-mesityl-2,3-dihydro-1H-imidazol-2-yl)gold(I)chloride; tetrabutyl ammonium fluoride; hydrogen; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; hexane; dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
DOI:10.1039/c5ob01286d