Technology Process of 2H-Pyran-2-one, 3-iodo-6-(4-methoxyphenyl)-
There total 3 articles about 2H-Pyran-2-one, 3-iodo-6-(4-methoxyphenyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
6-(4-methoxyphenyl)-2H-pyran-2-one;
With
2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex;
In
tetrahydrofuran;
at -40 ℃;
for 1h;
Schlenk technique;
Inert atmosphere;
With
iodine;
In
tetrahydrofuran;
at -40 - 25 ℃;
regioselective reaction;
Schlenk technique;
Inert atmosphere;
DOI:10.1055/s-0037-1610215
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 0.25 h / -40 °C / Schlenk technique; Inert atmosphere
1.2: 0.5 h / -40 °C / Schlenk technique; Inert atmosphere
2.1: bis(dibenzylideneacetone)-palladium(0); trifuran-2-yl-phosphane / tetrahydrofuran / 12 h / 25 °C / Schlenk technique; Inert atmosphere
3.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 1 h / -40 °C / Schlenk technique; Inert atmosphere
3.2: -40 - 25 °C / Schlenk technique; Inert atmosphere
With
2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0);
In
tetrahydrofuran;
2.1: |Negishi Coupling;
DOI:10.1055/s-0037-1610215
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: bis(dibenzylideneacetone)-palladium(0); trifuran-2-yl-phosphane / tetrahydrofuran / 12 h / 25 °C / Schlenk technique; Inert atmosphere
2.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 1 h / -40 °C / Schlenk technique; Inert atmosphere
2.2: -40 - 25 °C / Schlenk technique; Inert atmosphere
With
2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; trifuran-2-yl-phosphane; bis(dibenzylideneacetone)-palladium(0);
In
tetrahydrofuran;
1.1: |Negishi Coupling;
DOI:10.1055/s-0037-1610215
