N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide

Base Information

Chemical Name:N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide
CAS No.:68573-24-0
Molecular Formula:C19H18N2O3
Molecular Weight:322.364
Hs Code.:
DSSTox Substance ID:DTXSID901313118
Wikidata:Q105308384,Q105308386
Mol file:68573-24-0.mol

Synonyms:N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide;DTXSID901313118;AKOS030242666;FT-0665200

Suppliers and Price of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(p-Coumaroyl)Serotonin
50mg
$ 525.00

Medical Isotopes, Inc.
N-(p-Coumaroyl)serotonin
10 mg
$ 290.00

ChemScene
N-(p-Coumaroyl)Serotonin
5mg
$ 100.00

Cayman Chemical
N-(p-Coumaroyl) Serotonin ≥95%
10mg
$ 190.00

Cayman Chemical
N-(p-Coumaroyl) Serotonin ≥95%
5mg
$ 102.00

Cayman Chemical
N-(p-Coumaroyl) Serotonin ≥95%
1mg
$ 28.00

Cayman Chemical
N-(p-Coumaroyl) Serotonin ≥95%
25mg
$ 406.00

Biosynth Carbosynth
N-(p-Coumaroyl) serotonin
25 mg
$ 500.00

Biosynth Carbosynth
N-(p-Coumaroyl) serotonin
50 mg
$ 700.00

Biosynth Carbosynth
N-(p-Coumaroyl) serotonin
5 mg
$ 200.00

Total 16 raw suppliers

Chemical Property of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide

Chemical Property:

Vapor Pressure:6.53E-20mmHg at 25°C
Melting Point:192-194?C
Boiling Point:694.2°Cat760mmHg
PKA:9.74±0.30(Predicted)
Flash Point:373.6°C
PSA：85.35000
Density:1.346g/cm³
LogP:3.34210
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:2.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:322.13174244
Heavy Atom Count:24
Complexity:446

Purity/Quality:

≥98% ^*data from raw suppliers

N-(p-Coumaroyl)Serotonin ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C=CC(=O)NCCC2=CNC3=C2C=C(C=C3)O)O
Uses N-(p-Coumaroyl) serotonin is an antioxidative phenolic naturally found in plants, including safflower seed and millet grain. It ameliorates atherosclerosis in vivo, reducing lesion area in mice and rabbits. N-(p-Coumaroyl) serotonin also suppresses inflammatory cytokine generation by human monocytes, augments fibroblast proliferation, and promotes relaxation of vascular smooth muscle cells in vitro.

Technology Process of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide

There total 7 articles about N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-3-(4-hydroxyphenyl)prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 50-67-9
3-(2-aminoethyl)-1H-indol-5-ol

: 7400-08-0,50940-26-6
p-Coumaric Acid

: 68573-24-0
N-p-coumaroylserotonin

Guidance literature:: p-Coumaric Acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

3-(2-aminoethyl)-1H-indol-5-ol; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1248/cpb.c17-00416