Technology Process of 1H-Indole-1-carboxylic acid, 3-benzoyl-, methyl ester
There total 7 articles about 1H-Indole-1-carboxylic acid, 3-benzoyl-, methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 65 percent / Et4NBr, NaOH / CH2Cl2 / 0.5 h / 0 °C
2: AcOH, 50percent H2SO4 (1 : 1) / 4 h / Heating
3: 1.) 80percent NaH / 1.) DMF, 5 min, 2.) DMF, 1 h, 0 deg C
With
sodium hydroxide; sulfuric acid; tetraethylammonium bromide; sodium hydride; acetic acid;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: AcOH, 50percent H2SO4 (1 : 1) / 4 h / Heating
2: 65 percent / Et4NBr, NaOH / CH2Cl2 / 0.5 h / 0 °C
3: AcOH, 50percent H2SO4 (1 : 1) / 4 h / Heating
4: 1.) 80percent NaH / 1.) DMF, 5 min, 2.) DMF, 1 h, 0 deg C
With
sodium hydroxide; sulfuric acid; tetraethylammonium bromide; sodium hydride; acetic acid;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 3.9 percent / Et3N / diethyl ether / 48 h / Ambient temperature
2: AcOH, 50percent H2SO4 (1 : 1) / 0.25 h / Heating
With
sulfuric acid; acetic acid; triethylamine;
In
diethyl ether;