Isoxazole, 5-[(2S,3R,5S,6S)-5,6-dimethoxy-3,5,6-trimethyl-1,4-dioxan-2-yl]-3-[2-[( S)-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-oxazolylmethyl]-4-oxazolyl]-4, 5-dihydro-, (5R)-

Base Information

Chemical Name:Isoxazole, 5-[(2S,3R,5S,6S)-5,6-dimethoxy-3,5,6-trimethyl-1,4-dioxan-2-yl]-3-[2-[( S)-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-oxazolylmethyl]-4-oxazolyl]-4, 5-dihydro-, (5R)-
CAS No.:914933-35-0
Molecular Formula:C35H43N3O8Si
Molecular Weight:661.827
Hs Code.:

Isoxazole,
5-[(2S,3R,5S,6S)-5,6-dimethoxy-3,5,6-trimethyl-1,4-dioxan-2-yl]-3-[2-[(
S)-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-oxazolylmethyl]-4-oxazolyl]-4,
5-dihydro-, (5R)-

Synonyms:

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Chemical Property of Isoxazole, 5-[(2S,3R,5S,6S)-5,6-dimethoxy-3,5,6-trimethyl-1,4-dioxan-2-yl]-3-[2-[( S)-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-oxazolylmethyl]-4-oxazolyl]-4, 5-dihydro-, (5R)-

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Technology Process of Isoxazole, 5-[(2S,3R,5S,6S)-5,6-dimethoxy-3,5,6-trimethyl-1,4-dioxan-2-yl]-3-[2-[( S)-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-oxazolylmethyl]-4-oxazolyl]-4, 5-dihydro-, (5R)-

There total 7 articles about Isoxazole, 5-[(2S,3R,5S,6S)-5,6-dimethoxy-3,5,6-trimethyl-1,4-dioxan-2-yl]-3-[2-[( S)-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-5-oxazolylmethyl]-4-oxazolyl]-4, 5-dihydro-, (5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 947771-03-1
2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde oxime

: 914933-38-3
(2S,3S,5R,6R)-2,3-Dimethoxy-2,3,5-trimethyl-6-vinyl-[1,4]dioxane

: 914933-35-0
3-{2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazol-4-yl}-5-(5,6-dimethoxy-3,5,6-trimethyl-[1,4]dioxan-2-yl)-4,5-dihydro-isoxazole

: (R)-1-{2-[(S)-(tert-butyldiphenylsilyloxy)oxazol-5-ylmethyl]oxazol-4-yl}-3-[(2R,3R,5S,6S)-5,6-dimethoxy-3,5,6-trimethyl-[1,4]dioxan-2-yl]-3-hydroxypropan-1-one

Guidance literature:: 2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazole-4-carbaldehyde oxime; With pyridine; N-chloro-succinimide; In dichloromethane; at 20 ℃;

(2S,3S,5R,6R)-2,3-Dimethoxy-2,3,5-trimethyl-6-vinyl-[1,4]dioxane; With caesium carbonate; In 1,2-dimethoxyethane; at 20 ℃;
DOI:10.1002/anie.200602050

Reference yield: 60.0%

: C₂₄H₂₄ClN₃O₄Si

: 914933-38-3
(2S,3S,5R,6R)-2,3-Dimethoxy-2,3,5-trimethyl-6-vinyl-[1,4]dioxane

: 914933-35-0
3-{2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazol-4-yl}-5-(5,6-dimethoxy-3,5,6-trimethyl-[1,4]dioxan-2-yl)-4,5-dihydro-isoxazole

: (R)-1-{2-[(S)-(tert-butyldiphenylsilyloxy)oxazol-5-ylmethyl]oxazol-4-yl}-3-[(2R,3R,5S,6S)-5,6-dimethoxy-3,5,6-trimethyl-[1,4]dioxan-2-yl]-3-hydroxypropan-1-one

: C₄₈H₄₆N₆O₈Si₂

Guidance literature:: With CsCO₃; In 1,2-dimethoxyethane; at 0 ℃; for 18h;
DOI:10.1002/chem.200700033

Reference yield:

: 914933-47-4
(2S,3R,5S,6S)-5,6-dimethoxy-3,5,6-trimethyl-[1,4]dioxane-2-carbaldehyde

: 914933-35-0
3-{2-[(tert-butyl-diphenyl-silanyloxy)-oxazol-5-yl-methyl]-oxazol-4-yl}-5-(5,6-dimethoxy-3,5,6-trimethyl-[1,4]dioxan-2-yl)-4,5-dihydro-isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / KHMDS / tetrahydrofuran / -78 - 20 °C

2.1: N-chlorosuccinimide; pyridine / CH₂Cl₂ / 20 °C

2.2: 60 percent / Cs₂CO₃ / 1,2-dimethoxy-ethane / 20 °C

With pyridine; N-chloro-succinimide; potassium hexamethylsilazane; In tetrahydrofuran; dichloromethane; 1.1: Wittig reaction;
DOI:10.1002/anie.200602050