3-[4-(4-hydroxyphenyl)-5-oxohexan-3-yl]benzoic acid

Base Information

• Chemical Name: 3-[4-(4-hydroxyphenyl)-5-oxohexan-3-yl]benzoic acid
• CAS No.: 7146-75-0
• Molecular Formula: C₁₉H₂₀O₄
• Molecular Weight: 312.365
• Mol file: 7146-75-0.mol

Synonyms:Benzoicacid, m-(b-acetyl-a-ethyl-p-hydroxyphenethyl)-(8CI); NSC 23424; NSC 23425

Chemical Property of 3-[4-(4-hydroxyphenyl)-5-oxohexan-3-yl]benzoic acid

Chemical Property:

• Vapor Pressure: 8.11E-10mmHg at 25°C
• Boiling Point: 474.7°Cat760mmHg
• Flash Point: 255°C
• Density: 1.208g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[4-(4-hydroxyphenyl)-5-oxohexan-3-yl]benzoic acid

There total 9 articles about 3-[4-(4-hydroxyphenyl)-5-oxohexan-3-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) → 3-[1-ethyl-2-(4-hydroxy-phenyl)-3-oxo-butyl]-benzoic acid (7146-75-0)

Guidance literature:

Multi-step reaction with 7 steps

1: ethanolic sodium ethylate

2: diethyl ether

3: aqueous NaOH; ethylene glycol

4: Erwaermen des erhaltenen Saeurechlorids mit Aethoxomagnesio-malonsaeure-diaethylester in Aether und Erhitzen des Reaktionsprodukts mit wss.H₂SO₄ und Essigsaeure

5: CuCN; quinoline

6: aq.-ethanolic KOH

7: pyridine hydrochloride

With quinoline; potassium hydroxide; sodium hydroxide; diethyl ether; sodium ethanolate; pyridine hydrochloride; ethylene glycol;

DOI:10.1021/ja01645a017

Reference yield:

3c-(3-bromo-phenyl)-2-(4-methoxy-phenyl)-acrylonitrile → 3-[1-ethyl-2-(4-hydroxy-phenyl)-3-oxo-butyl]-benzoic acid (7146-75-0)

Guidance literature:

Multi-step reaction with 6 steps

1: diethyl ether

2: aqueous NaOH; ethylene glycol

3: Erwaermen des erhaltenen Saeurechlorids mit Aethoxomagnesio-malonsaeure-diaethylester in Aether und Erhitzen des Reaktionsprodukts mit wss.H₂SO₄ und Essigsaeure

4: CuCN; quinoline

5: aq.-ethanolic KOH

6: pyridine hydrochloride

With quinoline; potassium hydroxide; sodium hydroxide; diethyl ether; pyridine hydrochloride; ethylene glycol;

DOI:10.1021/ja01645a017

Reference yield:

p-methoxybenzylnitrile (104-47-2) → 3-[1-ethyl-2-(4-hydroxy-phenyl)-3-oxo-butyl]-benzoic acid (7146-75-0)

Guidance literature:

Multi-step reaction with 7 steps

1: ethanolic sodium ethylate

2: diethyl ether

3: aqueous NaOH; ethylene glycol

4: Erwaermen des erhaltenen Saeurechlorids mit Aethoxomagnesio-malonsaeure-diaethylester in Aether und Erhitzen des Reaktionsprodukts mit wss.H₂SO₄ und Essigsaeure

5: CuCN; quinoline

6: aq.-ethanolic KOH

7: pyridine hydrochloride

With quinoline; potassium hydroxide; sodium hydroxide; diethyl ether; sodium ethanolate; pyridine hydrochloride; ethylene glycol;

DOI:10.1021/ja01645a017

upstream raw materials:

3-[1-ethyl-2-(4-methoxy-phenyl)-3-oxo-butyl]-benzoic acid

m-bromobenzoic aldehyde

3-(3-bromo-phenyl)-2-(4-methoxy-phenyl)-valeronitrile

4-(3-bromo-phenyl)-3-(4-methoxy-phenyl)-hexan-2-one