p-Hydroxybiphenylacetic acid

Base Information

• Chemical Name: p-Hydroxybiphenylacetic acid
• CAS No.: 51350-23-3
• Molecular Formula: C14H12 O3
• Molecular Weight: 228.247
• Hs Code.: 2922299090
• Mol file: 51350-23-3.mol

Synonyms:4-(4-Hydroxyphenyl)phenylaceticacid; 4'-Hydroxy(1,1'-biphenyl)-4-acetic acid; 4'-Hydroxy-4-biphenylaceticacid; p-Hydroxybiphenylacetic acid

Chemical Property of p-Hydroxybiphenylacetic acid

Chemical Property:

• Boiling Point: 435°Cat760mmHg
• Flash Point: 231°C
• PSA: 57.53000
• Density: 1.263g/cm³
• LogP: 2.68630

Purity/Quality:

98%Min ^*data from raw suppliers

[1,1'-BIPHENYL]-4-ACETIC ACID,4'-HYDROXY- 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-Hydroxybiphenylacetic acid

There total 7 articles about p-Hydroxybiphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl (4'-methoxy-1,1'-biphenyl-4-yl) acetate (352652-78-9) → 2-(4'-hydroxy-[1,1'-biphenyl]-4-yl)acetic acid (51350-23-3)

Guidance literature:

With hydrogen bromide; acetic acid; for 8h; Heating / reflux;

Reference yield:

(4-bromo-phenyl)-acetic acid methyl ester (41841-16-1) → 2-(4'-hydroxy-[1,1'-biphenyl]-4-yl)acetic acid (51350-23-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ethanol; water; toluene / 8 h / Heating / reflux

2: water / hydrogen bromide / acetic acid / 8 h / Heating / reflux

With water; sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen bromide; In ethanol; water; acetic acid; toluene;

Reference yield:

2-(4-bromophenyl)-acetic acid (1878-68-8) → 2-(4'-hydroxy-[1,1'-biphenyl]-4-yl)acetic acid (51350-23-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 2 h / 0 - 20 °C

2: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / ethanol; water; toluene / 8 h / Heating / reflux

3: water / hydrogen bromide / acetic acid / 8 h / Heating / reflux

With sulfuric acid; water; sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydrogen bromide; In ethanol; water; acetic acid; toluene;

upstream raw materials:

2-(4'-methoxy-[1,1'-biphenyl]-4-yl)acetic acid

4-[(4'-methoxy-biphenyl-4-yl)-thioacetyl]-morpholine

1-(4'-methoxy-biphenyl-4-yl)-ethanone

methyl (4'-methoxy-1,1'-biphenyl-4-yl) acetate

Downstream raw materials:

2-{4'-[(5-Chloro-2-methoxy-phenylcarbamoyl)-methyl]-biphenyl-4-yloxy}-2-methyl-propionic acid ethyl ester

methyl (4'-hydroxy-1,1'-biphenyl-4-yl)acetate

4-(5-Chloro-2-methoxy-anilino-carbonyl-methyl)-4'-hydroxybiphenyl

Refernces

• 1、 -. "SUBSTITUTED INDOLE COMPOUND". Page/Page column 144. . Retrieved 2010/11/24.