5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6,7-dihydro-2-methyl-5-oxo-6-(tetrahydro-2H-thio pyran-4-yl)-, phenylmethyl ester

Base Information

• Chemical Name: 5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6,7-dihydro-2-methyl-5-oxo-6-(tetrahydro-2H-thio pyran-4-yl)-, phenylmethyl ester
• CAS No.: 915297-09-5
• Molecular Formula: C27H24Cl2N2O3S
• Molecular Weight: 527.471
• Mol file: 915297-09-5.mol

Synonyms:

Chemical Property of 5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6,7-dihydro-2-methyl-5-oxo-6-(tetrahydro-2H-thio pyran-4-yl)-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6,7-dihydro-2-methyl-5-oxo-6-(tetrahydro-2H-thio pyran-4-yl)-, phenylmethyl ester

There total 1 articles about 5H-Pyrrolo[3,4-b]pyridine-3-carboxylic acid, 4-(2,4-dichlorophenyl)-6,7-dihydro-2-methyl-5-oxo-6-(tetrahydro-2H-thio pyran-4-yl)-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-tetrahydrothiopyranylamine (21926-00-1) + 3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methylpyridine-3,5-dicarboxylate (915296-81-0,915731-56-5,915731-57-6) → benzyl 4-(2,4-dichlorophenyl)-2-(methyl-5-oxo-6-tetrahydro-2H-thiopyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate (915297-09-5)

Guidance literature:

In ethanol; at 150 ℃; for 0.5h; Microwave;

Reference yield: 98.0%

benzyl 4-(2,4-dichlorophenyl)-2-(methyl-5-oxo-6-tetrahydro-2H-thiopyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate (915297-09-5) → Benzyl 4-(2,4-dichlorophenyl)-2-methyl-5-oxo-6-(tetrahydro-1,1-dioxo-2H-thiopyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate (915297-10-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

4-tetrahydrothiopyranylamine

3-benzyl 5-ethyl 6-(chloromethyl)-4-(2,4-dichlorophenyl)-2-methylpyridine-3,5-dicarboxylate

Downstream raw materials:

Benzyl 4-(2,4-dichlorophenyl)-2-methyl-5-oxo-6-(tetrahydro-1,1-dioxo-2H-thiopyran-4-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylate