Carbobenzoxyprolyl-leucyl-glycinamide

Base Information

• Chemical Name: Carbobenzoxyprolyl-leucyl-glycinamide
• CAS No.: 14485-80-4
• Molecular Formula: C21H30N4O5
• Molecular Weight: 418.493
• DSSTox Substance ID: DTXSID30932426
• Wikidata: Q82908124
• Mol file: 14485-80-4.mol

Synonyms:carbobenzoxyprolyl-leucyl-glycinamide;Z-PLG;Z-Pro-Leu-Gly-NH2

Chemical Property of Carbobenzoxyprolyl-leucyl-glycinamide

Chemical Property:

• Vapor Pressure: 3.14E-21mmHg at 25°C
• Refractive Index: 1.556
• Boiling Point: 731 °C at 760 mmHg
• Flash Point: 395.9 °C
• PSA: 130.83000
• Density: 1.195 g/cm³
• LogP: 2.34000
• Storage Temp.: -15°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 418.22162007
• Heavy Atom Count: 30
• Complexity: 604

Purity/Quality:

99% ^*data from raw suppliers

Z-PRO-LEU-GLY-NH2 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NCC(=O)NC(=O)OCC1=CC=CC=C1)NC(=O)C2CCCN2
• Isomeric SMILES: CC(C)C[C@@H](C(=O)NCC(=O)NC(=O)OCC1=CC=CC=C1)NC(=O)[C@@H]2CCCN2

Technology Process of Carbobenzoxyprolyl-leucyl-glycinamide

There total 14 articles about Carbobenzoxyprolyl-leucyl-glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

N-[N-(N-benzyloxycarbonyl-L-prolyl)-L-leucyl]glycine ethyl ester (7784-82-9) → benzoyloxycarbonylprolyl-leucyl-glycine amide (14485-80-4)

Guidance literature:

With ammonia; In methanol; at 0 - 30 ℃;

Reference yield: 88.0%

-L-leucine methyl ester (2873-37-2) + glycine amide hydrobromide (55264-42-1) → benzoyloxycarbonylprolyl-leucyl-glycine amide (14485-80-4)

Guidance literature:

With triethylamine; proteinase K; In acetonitrile; at 30 ℃; for 48h;

Reference yield: 86.0%

Z-Pro-Leu-Gly-OBg (119706-28-4) → benzoyloxycarbonylprolyl-leucyl-glycine amide (14485-80-4)

Guidance literature:

With ammonium hydroxide; In N,N-dimethyl-formamide; for 0.25h; Ambient temperature;

DOI:10.1016/S0040-4020(01)86014-2

upstream raw materials:

N-[N-(N-benzyloxycarbonyl-L-prolyl)-L-leucyl]glycine ethyl ester

N-Benzyloxycarbonyl-L-proline

-L-leucine methyl ester

glycine amide hydrobromide

Downstream raw materials:

melanostatin

N-methyl N-nitrosocarbamoyl L-prolyl L-leucyl glycinamide

N-(chloro-2-ethyl) N-nitrosocarbamoyl L-prolyl L-leucyl glycinamide

Cbz-Pro-Leu-Gly-OCH₃