5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[[[4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)- 1-piperazinyl]carbonyl]oxy]methyl]-8-oxo-7-[(2-phenylacetyl)amino]-, 2-(diphenylmethyl) ester, (6R,7R)-

Base Information

Chemical Name:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[[[4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)- 1-piperazinyl]carbonyl]oxy]methyl]-8-oxo-7-[(2-phenylacetyl)amino]-, 2-(diphenylmethyl) ester, (6R,7R)-
CAS No.:915939-01-4
Molecular Formula:C47H42FN5O9S
Molecular Weight:871.943
Hs Code.:

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
3-[[[[4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)-
1-piperazinyl]carbonyl]oxy]methyl]-8-oxo-7-[(2-phenylacetyl)amino]-,
2-(diphenylmethyl) ester, (6R,7R)-

Synonyms:

Suppliers and Price of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[[[4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)- 1-piperazinyl]carbonyl]oxy]methyl]-8-oxo-7-[(2-phenylacetyl)amino]-, 2-(diphenylmethyl) ester, (6R,7R)-

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Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[[[4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)- 1-piperazinyl]carbonyl]oxy]methyl]-8-oxo-7-[(2-phenylacetyl)amino]-, 2-(diphenylmethyl) ester, (6R,7R)-

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Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[[[4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)- 1-piperazinyl]carbonyl]oxy]methyl]-8-oxo-7-[(2-phenylacetyl)amino]-, 2-(diphenylmethyl) ester, (6R,7R)-

There total 5 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[[[[4-(3-carboxy-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl)- 1-piperazinyl]carbonyl]oxy]methyl]-8-oxo-7-[(2-phenylacetyl)amino]-, 2-(diphenylmethyl) ester, (6R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.4%

: 142478-57-7
8-oxo-7-phenylacetylamino-3-(2,3,3,3-tetrachloro-propionyloxymethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

: 85721-33-1,178489-05-9,189257-90-7
ciprofloxacin

: 915939-01-4
7-[4-(2-benzhydryloxycarbonyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethoxycarbonyl)-piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:: ciprofloxacin; With sodium hydrogencarbonate; at 45 ℃; for 0.583333h;

8-oxo-7-phenylacetylamino-3-(2,3,3,3-tetrachloro-propionyloxymethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester; In 1,4-dioxane; at 20 ℃; for 1.5h;
DOI:10.1016/j.bmcl.2006.08.045

Reference yield:

: 35246-64-1
(6R,7R)-benzhydryl 3-(hydroxymethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

: 915939-01-4
7-[4-(2-benzhydryloxycarbonyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethoxycarbonyl)-piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81.5 percent / pyridine / CH₂Cl₂ / 0.58 h / 0 °C

2.1: aq. NaHCO₃ / 0.58 h / 45 °C

2.2: 80.4 percent / dioxane / 1.5 h / 20 °C

With pyridine; sodium hydrogencarbonate; In dichloromethane;
DOI:10.1016/j.bmcl.2006.08.045

Reference yield:

: 15690-38-7
(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 915939-01-4
7-[4-(2-benzhydryloxycarbonyl-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethoxycarbonyl)-piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: BSA / N,N-dimethyl-acetamide / 0.5 h / 20 °C

1.2: 100 percent / N,N-dimethyl-acetamide / 1.5 h / -20 - -10 °C

2.1: 56 percent / ethyl acetate / 1 h / 20 °C

3.1: 81.5 percent / pyridine / CH₂Cl₂ / 0.58 h / 0 °C

4.1: aq. NaHCO₃ / 0.58 h / 45 °C

4.2: 80.4 percent / dioxane / 1.5 h / 20 °C

With pyridine; benzenesulfonamide; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl acetamide; ethyl acetate;
DOI:10.1016/j.bmcl.2006.08.045