Technology Process of 4,12-Dioxa-3,13-disilapentadeca-6,7-diene,
2,2,8,13,13,14,14-heptamethyl-3,3-diphenyl-5-[4-(trimethylsilyl)-3-butyn-
1-yl]-
There total 5 articles about 4,12-Dioxa-3,13-disilapentadeca-6,7-diene,
2,2,8,13,13,14,14-heptamethyl-3,3-diphenyl-5-[4-(trimethylsilyl)-3-butyn-
1-yl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyllithium;
With
copper(l) iodide;
In
tetrahydrofuran; diethyl ether;
at -30 - 0 ℃;
for 0.5h;
methanesulfonic acid 6-(tert-butyl-dimethyl-silanyloxy)-1-[1-(tert-butyl-diphenyl-silanyloxy)-5-trimethylsilanyl-pent-4-ynyl]-hex-2-ynyl ester;
In
tetrahydrofuran; diethyl ether;
at -78 ℃;
for 1h;
Title compound not separated from byproducts;
DOI:10.1016/j.tet.2006.06.115
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 80 percent / i-PrMgCl / tetrahydrofuran / 0 °C
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 - -20 °C
2.2: tetrahydrofuran; hexane / 2 h / -78 - 0 °C
3.1: 772 mg / CeCl3*7H2O; NaBH4 / methanol / -20 - 0 °C
4.1: Et3N / CH2Cl2 / 0.5 h / 0 °C
5.1: copper(I) iodide / tetrahydrofuran; diethyl ether / 0.5 h / -30 - 0 °C
5.2: tetrahydrofuran; diethyl ether / 1 h / -78 °C
With
sodium tetrahydroborate; copper(l) iodide; n-butyllithium; cerium(III) chloride; isopropylmagnesium chloride; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
3.1: Luche reduction;
DOI:10.1016/j.tet.2006.06.115
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 772 mg / CeCl3*7H2O; NaBH4 / methanol / -20 - 0 °C
2.1: Et3N / CH2Cl2 / 0.5 h / 0 °C
3.1: copper(I) iodide / tetrahydrofuran; diethyl ether / 0.5 h / -30 - 0 °C
3.2: tetrahydrofuran; diethyl ether / 1 h / -78 °C
With
sodium tetrahydroborate; copper(l) iodide; cerium(III) chloride; triethylamine;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
1.1: Luche reduction;
DOI:10.1016/j.tet.2006.06.115
![methanesulfonic acid 6-(<i>tert</i>-butyl-dimethyl-silanyloxy)-1-[1-(<i>tert</i>-butyl-diphenyl-silanyloxy)-5-trimethylsilanyl-pent-4-ynyl]-hex-2-ynyl ester](/Databaselist/images/loading.webp)
