Carbamic acid, N-[(1S)-2-[(5S)-2-(dimethylphenylsilyl)-5-(methoxymethyl)-1-pyrrolidinyl]- 1-(hydroxymethyl)-2-oxoethyl]-, 1,1-dimethylethyl ester

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Chemical Name:Carbamic acid, N-[(1S)-2-[(5S)-2-(dimethylphenylsilyl)-5-(methoxymethyl)-1-pyrrolidinyl]- 1-(hydroxymethyl)-2-oxoethyl]-, 1,1-dimethylethyl ester
CAS No.:916049-23-5
Molecular Formula:C22H36N2O5Si
Molecular Weight:436.624
Hs Code.:

Carbamic acid,
N-[(1S)-2-[(5S)-2-(dimethylphenylsilyl)-5-(methoxymethyl)-1-pyrrolidinyl]-
1-(hydroxymethyl)-2-oxoethyl]-, 1,1-dimethylethyl ester

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Chemical Property of Carbamic acid, N-[(1S)-2-[(5S)-2-(dimethylphenylsilyl)-5-(methoxymethyl)-1-pyrrolidinyl]- 1-(hydroxymethyl)-2-oxoethyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, N-[(1S)-2-[(5S)-2-(dimethylphenylsilyl)-5-(methoxymethyl)-1-pyrrolidinyl]- 1-(hydroxymethyl)-2-oxoethyl]-, 1,1-dimethylethyl ester

There total 7 articles about Carbamic acid, N-[(1S)-2-[(5S)-2-(dimethylphenylsilyl)-5-(methoxymethyl)-1-pyrrolidinyl]- 1-(hydroxymethyl)-2-oxoethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 916049-16-6
2-methoxymethylpyrrolidine-1-carboxylic acid tert-butyl ester

: 916049-23-5
{2-[2-(dimethylphenylsilyl)-5-(methoxymethyl)pyrrolidin-1-yl]-1-hydroxymethyl-2-oxoethyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 72 percent / tetraethylammonium tosylate / Electrolysis

2.1: lithium / tetrahydrofuran / 12 h / 20 °C

2.2: copper cyanide / tetrahydrofuran; diethyl ether / 0.17 h / 20 °C

2.3: 61 percent / BF₃*OEt₂ / tetrahydrofuran; diethyl ether / 3 h / -40 °C

3.1: aq. HCl / ethyl acetate / 0.5 h / 20 °C

4.1: 668 mg / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; lithium; tetraethylammonium tosylate; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja064737l

Reference yield:

: 916049-17-7
2-methoxy-5-methoxymethylpyrrolidine-1-carboxylic acid tert-butyl ester

: 916049-23-5
{2-[2-(dimethylphenylsilyl)-5-(methoxymethyl)pyrrolidin-1-yl]-1-hydroxymethyl-2-oxoethyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium / tetrahydrofuran / 12 h / 20 °C

1.2: copper cyanide / tetrahydrofuran; diethyl ether / 0.17 h / 20 °C

1.3: 61 percent / BF₃*OEt₂ / tetrahydrofuran; diethyl ether / 3 h / -40 °C

2.1: aq. HCl / ethyl acetate / 0.5 h / 20 °C

3.1: 668 mg / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; lithium; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja064737l

Reference yield:

: 916049-21-3
2-(dimethylphenylsilyl)-5-methoxymethylpyrrolidine-1-carboxylic acid tert-butyl ester

: 916049-23-5
{2-[2-(dimethylphenylsilyl)-5-(methoxymethyl)pyrrolidin-1-yl]-1-hydroxymethyl-2-oxoethyl}carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / ethyl acetate / 0.5 h / 20 °C

2: 668 mg / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; In dichloromethane; ethyl acetate;
DOI:10.1021/ja064737l