1-Carboxyglutamic Acid

Base Information

• Chemical Name: 1-Carboxyglutamic Acid
• CAS No.: 53445-96-8
• Molecular Formula: C₆H₉NO₆
• Molecular Weight: 191.141
• Mol file: 53445-96-8.mol

Synonyms:1,1,3-Propanetricarboxylicacid, 3-amino-, (?à)-;(?à)-3-Amino-1,1,3-propanetricarboxylicacid; 3-Amino-1,1,3-propanetricarboxylic acid; DL-g-Carboxyglutamic acid

Chemical Property of 1-Carboxyglutamic Acid

Chemical Property:

• Boiling Point: 418°Cat760mmHg
• Flash Point: 206.6°C
• PSA: 137.92000
• Density: 1.649g/cm³
• LogP: -0.72590

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Carboxyglutamic Acid

There total 32 articles about 1-Carboxyglutamic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-tert-butyloxycarbonyl-L-γ-carboxyglutamic acid (95586-48-4) → γ-carboxy-L-glutamic acid (53861-57-7,53445-96-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 0.5h; Ambient temperature;

Reference yield: 82.0%

N-benzyloxycarbonyl-γ-carboxy-L-glutamic acid (97458-26-9,120824-82-0) → γ-carboxy-L-glutamic acid (53861-57-7,53445-96-8)

Guidance literature:

With hydrogen;

Reference yield: 15.0%

H-L-Gla(OBn)2-OH hydrochloride → γ-carboxy-L-glutamic acid (53861-57-7,53445-96-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1039/b004677i

upstream raw materials:

2-Benzyloxycarbonyl-4-benzyloxycarbonylamino-pentanedioic acid dibenzyl ester

γ,γ'-Di-tert-butyl-DL-γ-carboxyglutamic acid

N-benzyloxycarbonyl-γ-carboxy-DL-glutamic acid

ethyl (+/-)-2,2-dimethyl-α-nitro-4,6-dioxo-1,3-dioxane-5-propanoate

Downstream raw materials:

4,4-dicarboxy-5-(p-methoxyphenyl)proline

4,4-dicarboxy-5-phenylproline

4,4-dicarboxy-5-(p-nitrophenyl)proline

Refernces

• 1、 Zia-Ebrahimi,Huffman. "Synthesis and utility of a novel methylene Meldrum's acid precursor". . p. 215 - 218. Retrieved 1996.
• 2、 Morris et al.. "". . p. 856. Retrieved 1975.
• 3、 -. "Azapeptides useful in the treatment of Hepatitis C". . . Retrieved 2008/06/13.