1H-Pyrazolo[4,3-d]pyrimidin-5-amine, N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphen yl)-1-[(4-methoxyphenyl)methyl]-

Base Information

Chemical Name:1H-Pyrazolo[4,3-d]pyrimidin-5-amine, N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphen yl)-1-[(4-methoxyphenyl)methyl]-
CAS No.:916065-30-0
Molecular Formula:C29H24ClF4N5O2
Molecular Weight:585.988
Hs Code.:

1H-Pyrazolo[4,3-d]pyrimidin-5-amine,
N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphen
yl)-1-[(4-methoxyphenyl)methyl]-

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Chemical Property of 1H-Pyrazolo[4,3-d]pyrimidin-5-amine, N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphen yl)-1-[(4-methoxyphenyl)methyl]-

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Technology Process of 1H-Pyrazolo[4,3-d]pyrimidin-5-amine, N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphen yl)-1-[(4-methoxyphenyl)methyl]-

There total 9 articles about 1H-Pyrazolo[4,3-d]pyrimidin-5-amine, N-[2-chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphen yl)-1-[(4-methoxyphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-Amino-1-(4-methoxybenzyl)-1H-pyrazole-3-carboxamide hydrochloride

: 916065-30-0
N-[2-Chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphenyl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-d]pyrimidine-5-amine

Guidance literature:: Multi-step reaction with 5 steps

1: ethylene glycol / 2 h / 200 °C

2: trichlorophosphate / toluene / 1.5 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1 h / Heating / reflux

4: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Heating / reflux

5: sodium hydride / N,N-dimethyl-formamide / 0.53 h / Cooling with acetone-ice

With sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; ethylene glycol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 5,7-dichloro-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-d]pyrimidine

: 916065-30-0
N-[2-Chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphenyl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-d]pyrimidine-5-amine

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1 h / Heating / reflux

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Heating / reflux

3: sodium hydride / N,N-dimethyl-formamide / 0.53 h / Cooling with acetone-ice

With sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 896467-74-6
methyl 1-(4-methoxybenzyl)-4-nitro-1H-pyrazole-3-carboxylate

: 916065-30-0
N-[2-Chloro-4-(trifluoromethyl)phenyl]-N-ethyl-7-(2-fluoro-6-methoxyphenyl)-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-d]pyrimidine-5-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol; ammonia / 20 °C

2.1: hydrogenchloride; iron / ethanol; water / 1.5 h / 80 °C

2.2: pH 8

3.1: ethylene glycol / 2 h / 200 °C

4.1: trichlorophosphate / toluene / 1.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 1 h / Heating / reflux

6.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / Heating / reflux

7.1: sodium hydride / N,N-dimethyl-formamide / 0.53 h / Cooling with acetone-ice

With hydrogenchloride; methanol; ammonia; iron; sodium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; water; ethylene glycol; N,N-dimethyl-formamide; toluene;