Methanesulfonic acid, 1,1,1-trifluoro-, 2-[[[(2S)-1-[3-(1-methyl-1H-benzimidazol-2-yl)-1-oxopropyl]-2-pyrrolidin yl]carbonyl]amino]phenyl ester

Base Information

Chemical Name:Methanesulfonic acid, 1,1,1-trifluoro-, 2-[[[(2S)-1-[3-(1-methyl-1H-benzimidazol-2-yl)-1-oxopropyl]-2-pyrrolidin yl]carbonyl]amino]phenyl ester
CAS No.:916142-26-2
Molecular Formula:C23H23F3N4O5S
Molecular Weight:524.521
Hs Code.:

Methanesulfonic acid, 1,1,1-trifluoro-,
2-[[[(2S)-1-[3-(1-methyl-1H-benzimidazol-2-yl)-1-oxopropyl]-2-pyrrolidin
yl]carbonyl]amino]phenyl ester

Synonyms:

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Chemical Property of Methanesulfonic acid, 1,1,1-trifluoro-, 2-[[[(2S)-1-[3-(1-methyl-1H-benzimidazol-2-yl)-1-oxopropyl]-2-pyrrolidin yl]carbonyl]amino]phenyl ester

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Technology Process of Methanesulfonic acid, 1,1,1-trifluoro-, 2-[[[(2S)-1-[3-(1-methyl-1H-benzimidazol-2-yl)-1-oxopropyl]-2-pyrrolidin yl]carbonyl]amino]phenyl ester

There total 7 articles about Methanesulfonic acid, 1,1,1-trifluoro-, 2-[[[(2S)-1-[3-(1-methyl-1H-benzimidazol-2-yl)-1-oxopropyl]-2-pyrrolidin yl]carbonyl]amino]phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(2-hydroxyphenyl)-1-[3-(1-methyl-1H-benzimidazol-2-yl)propanoyl]-L-prolinamide

: 358-23-6
trifluoromethylsulfonic anhydride

: 916142-26-2
2-({1-[3-(1-methyl-1H-benzimidazol-2-yl)propanoyl]-L-prolyl}amino)phenyl trifluoromethanesulfonate

Guidance literature:: With pyridine; at 0 ℃; for 0.5h;

Reference yield:

: C₁₆H₁₉N₃O₃

: 916142-26-2
2-({1-[3-(1-methyl-1H-benzimidazol-2-yl)propanoyl]-L-prolyl}amino)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 25 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 25 °C

2.2: pH 5

3.1: pyridine; trichlorophosphate / 0.5 h / -10 - 0 °C

4.1: hydrogen / palladium dihydroxide / methanol / 2 h / 20 °C

5.1: pyridine / 0.5 h / 0 °C

With pyridine; sodium hydroxide; water; hydrogen; caesium carbonate; trichlorophosphate; palladium dihydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: methyl 1-[3-(1-methyl-1H-benzimidazol-2-yl)propanoyl]-L-prolinate

: 916142-26-2
2-({1-[3-(1-methyl-1H-benzimidazol-2-yl)propanoyl]-L-prolyl}amino)phenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 2 h / 25 °C

1.2: pH 5

2.1: pyridine; trichlorophosphate / 0.5 h / -10 - 0 °C

3.1: hydrogen / palladium dihydroxide / methanol / 2 h / 20 °C

4.1: pyridine / 0.5 h / 0 °C

With pyridine; sodium hydroxide; water; hydrogen; trichlorophosphate; palladium dihydroxide; In tetrahydrofuran; methanol;