2-{Methoxy[1-(trimethylsilyl)cyclopropyl]methyl}cyclohexan-1-one

Base Information

Chemical Name:2-{Methoxy[1-(trimethylsilyl)cyclopropyl]methyl}cyclohexan-1-one
CAS No.:91633-62-4
Molecular Formula:C14H26O2Si
Molecular Weight:254.445
Hs Code.:
DSSTox Substance ID:DTXSID70529455

Synonyms:91633-62-4;DTXSID70529455;2-{Methoxy[1-(trimethylsilyl)cyclopropyl]methyl}cyclohexan-1-one;2-[METHOXY[1-(TRIMETHYLSILYL)CYCLOPROPYL]METHYL]CYCLOHEXANONE

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{Methoxy[1-(trimethylsilyl)cyclopropyl]methyl}cyclohexan-1-one

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:254.170206602
Heavy Atom Count:17
Complexity:302

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(C1CCCCC1=O)C2(CC2)[Si](C)(C)C

Technology Process of 2-{Methoxy[1-(trimethylsilyl)cyclopropyl]methyl}cyclohexan-1-one

There total 3 articles about 2-{Methoxy[1-(trimethylsilyl)cyclopropyl]methyl}cyclohexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 6651-36-1
1-(Trimethylsilyloxy)cyclohexene

: 91633-59-9
1-(Trimethylsilyl)cyclopropanecarboxaldehyde Dimethyl Acetal

: 91633-62-4
2-methyl>cyclohexanone

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 8h;
DOI:10.1021/jo00193a030

Reference yield:

: 91633-48-6
<1-(Trimethylsilyl)cyclopropyl>carbinol

: 91633-62-4
2-methyl>cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / MnO₂ / CH₂Cl₂ / 48 h / Ambient temperature

2: 90 percent / pyridinium tosylate / methanol; benzene / 15 h / Ambient temperature

3: 90 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 8 h / -78 °C

With manganese(IV) oxide; trimethylsilyl trifluoromethanesulfonate; pyridinium p-toluenesulfonate; In methanol; dichloromethane; benzene;
DOI:10.1021/jo00193a030

Reference yield:

: 91686-39-4
1-(Trimethylsilyl)cyclopropanenitrile

: 91633-62-4
2-methyl>cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1) diisobutylaluminium hydride, 2) 5percent sulfuric acid / 1) ether, -78 deg C, 2 h, 2) 1 h

2: 90 percent / pyridinium tosylate / methanol; benzene / 15 h / Ambient temperature

3: 90 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 8 h / -78 °C

With trimethylsilyl trifluoromethanesulfonate; sulfuric acid; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; In methanol; dichloromethane; benzene;
DOI:10.1021/jo00193a030