10-((ethoxycarbonyl)methoxy)-8-(4-(4-fluorophenyl)-1-methylbutyl)-1,2,3,4-tetrahydro-N,5,5-trimethyl-5H-(1)-benzopyrano(4,3-c)pyridine-2-acetamide

Base Information

Chemical Name:10-((ethoxycarbonyl)methoxy)-8-(4-(4-fluorophenyl)-1-methylbutyl)-1,2,3,4-tetrahydro-N,5,5-trimethyl-5H-(1)-benzopyrano(4,3-c)pyridine-2-acetamide
CAS No.:140676-68-2
Molecular Formula:C32H41 F N2 O5
Molecular Weight:0
Hs Code.:
Mol file:140676-68-2.mol

10-((ethoxycarbonyl)methoxy)-8-(4-(4-fluorophenyl)-1-methylbutyl)-1,2,3,4-tetrahydro-N,5,5-trimethyl-5H-(1)-benzopyrano(4,3-c)pyridine-2-acetamide

Synonyms:Aceticacid,[[8-[4-(4-fluorophenyl)-1-methylbutyl]-1,3,4,5-tetrahydro-5,5-dimethyl-2-[2-(methylamino)-2-oxoethyl]-2H-[1]benzopyrano[4,3-c]pyridin-10-yl]oxy]-,ethyl ester (9CI); 2H-[1]Benzopyrano[4,3-c]pyridine, acetic acid deriv.

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Chemical Property of 10-((ethoxycarbonyl)methoxy)-8-(4-(4-fluorophenyl)-1-methylbutyl)-1,2,3,4-tetrahydro-N,5,5-trimethyl-5H-(1)-benzopyrano(4,3-c)pyridine-2-acetamide

Chemical Property:

Vapor Pressure:3.21E-19mmHg at 25°C
Boiling Point:696°Cat760mmHg
Flash Point:374.7°C
PSA：80.59000
Density:1.2g/cm³
LogP:6.04850

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 10-((ethoxycarbonyl)methoxy)-8-(4-(4-fluorophenyl)-1-methylbutyl)-1,2,3,4-tetrahydro-N,5,5-trimethyl-5H-(1)-benzopyrano(4,3-c)pyridine-2-acetamide

There total 4 articles about 10-((ethoxycarbonyl)methoxy)-8-(4-(4-fluorophenyl)-1-methylbutyl)-1,2,3,4-tetrahydro-N,5,5-trimethyl-5H-(1)-benzopyrano(4,3-c)pyridine-2-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60926-09-2
8-[4-(4-fluoro-phenyl)-1-methyl-butyl]-5,5-dimethyl-1,3,4,5-tetrahydro-2H-chromeno[4,3-c]pyridin-10-ol

: 140676-68-2
{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-10,10-dimethyl-3-methylcarbamoylmethyl-2,3,4,10-tetrahydro-1H-9-oxa-3-aza-phenanthren-5-yloxy}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / TEA / CH₂Cl₂ / 5 h / Ambient temperature

2: 1.) NaH, 2.) KI / 1.) DMF, 80 deg C, 2 h, 2.) DMF, 80 deg C, 2 h

3: 4N HCl / dioxane / 2 h

4: TEA / dimethylformamide / 24 h

With hydrogenchloride; TEA; sodium hydride; potassium iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00089a016

Reference yield:

: 140676-65-9
7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydroxy-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthrene-3-carboxylic acid tert-butyl ester

: 140676-68-2
{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-10,10-dimethyl-3-methylcarbamoylmethyl-2,3,4,10-tetrahydro-1H-9-oxa-3-aza-phenanthren-5-yloxy}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH, 2.) KI / 1.) DMF, 80 deg C, 2 h, 2.) DMF, 80 deg C, 2 h

2: 4N HCl / dioxane / 2 h

3: TEA / dimethylformamide / 24 h

With hydrogenchloride; TEA; sodium hydride; potassium iodide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00089a016

Reference yield:

: 140676-69-3
5-Ethoxycarbonylmethoxy-7-[4-(4-fluoro-phenyl)-1-methyl-butyl]-10,10-dimethyl-1,2,4,10-tetrahydro-9-oxa-3-aza-phenanthrene-3-carboxylic acid tert-butyl ester

: 140676-68-2
{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-10,10-dimethyl-3-methylcarbamoylmethyl-2,3,4,10-tetrahydro-1H-9-oxa-3-aza-phenanthren-5-yloxy}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 4N HCl / dioxane / 2 h

2: TEA / dimethylformamide / 24 h

With hydrogenchloride; TEA; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00089a016