3-Hydrazino-6-(2-thienyl)pyridazine

Base Information

• Chemical Name: 3-Hydrazino-6-(2-thienyl)pyridazine
• CAS No.: 75792-87-9
• Molecular Formula: C₈H₈N₄S
• Molecular Weight: 192.244
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID60226704
• Nikkaji Number: J78.828G
• Wikidata: Q83106203
• ChEMBL ID: CHEMBL156907
• Mol file: 75792-87-9.mol

Synonyms:3-Hydrazino-6-(2-thienyl)pyridazine;75792-87-9;3-hydrazinyl-6-(thiophen-2-yl)pyridazine;Pyridazine, 3-hydrazino-6-(2-thienyl)-;(6-thiophen-2-ylpyridazin-3-yl)hydrazine;BRN 5933836;CHEMBL156907;DTXSID60226704;MFCD01692837;STK689817;AKOS005174786;BS-3641;1-[6-(2-Thienyl)pyridazin-3-yl]hydrazine;LS-129599;CS-0312737;FT-0769076;6-Hydrazono-3-(thiophen-2-yl)-1,6-dihydropyridazine;F1967-1130

Chemical Property of 3-Hydrazino-6-(2-thienyl)pyridazine

Chemical Property:

• Vapor Pressure: 6.87E-09mmHg at 25°C
• Boiling Point: 466.8°Cat760mmHg
• Flash Point: 236.1°C
• PSA: 92.07000
• Density: 1.4g/cm³
• LogP: 2.26400
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 192.04696745
• Heavy Atom Count: 13
• Complexity: 166

Purity/Quality:

98%min ^*data from raw suppliers

3-Hydrazino-6-(2-thienyl)pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CSC(=C1)C2=NN=C(C=C2)NN

Technology Process of 3-Hydrazino-6-(2-thienyl)pyridazine

There total 4 articles about 3-Hydrazino-6-(2-thienyl)pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-chloro-6-(2'-thienyl)pyridazine (28657-41-2) → 3-hydrazino-6-thien-2-ylpyridazine (75792-87-9)

Guidance literature:

With hydrazine hydrate; for 3h; Heating;

DOI:10.1021/jm00133a013

Reference yield:

6-(thien-2-yl)-2,3-dihydropyridazin-3-one (54558-07-5) → 3-hydrazino-6-thien-2-ylpyridazine (75792-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphorus oxychloride / 4 h / 85 - 95 °C

2: hydrazine hydrate / butan-1-ol / 6 h / 100 °C

With hydrazine hydrate; trichlorophosphate; In butan-1-ol;

DOI:10.1021/jm00385a003

Reference yield:

4-oxo-4-thiophen-2-yl-butyric acid (4653-08-1) → 3-hydrazino-6-thien-2-ylpyridazine (75792-87-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / N₂H₄*H₂O / ethanol / 7 h / Heating

2: 83 percent / O₂NC₆H₄SO₃Na-m, NaOH / H₂O; ethanol / 2 h / 100 °C

3: 68 percent / POCl₃ / 1.5 h / 135 °C

4: 85 percent / N₂H₄*H₂O / 3 h / Heating

With sodium hydroxide; hydrazine hydrate; sodium 3-nitrobenzenesulfonate; trichlorophosphate; In ethanol; water;

DOI:10.1021/jm00133a013

upstream raw materials:

3-chloro-6-(2'-thienyl)pyridazine

6-(thien-2-yl)-2,3-dihydropyridazin-3-one

4-oxo-4-thiophen-2-yl-butyric acid

6-(thien-2-yl)-2,3,4,5-tetrahydropyridazin-3-one

Refernces

• 1、 Steiner,Gries,Lenke. "Synthesis and antihypertensive activity of new 6-heteroaryl-3-hydrazinopyridazine derivatives". . p. 59 - 63. Retrieved 2007/10/02.