Isoquinolinium,4a-(2,3-dimethoxyphenyl)-3,4,4a,5,6,7,8,8a-octahydro-2-methyl-6-oxo-,cis-, perchlorate

Base Information

Chemical Name:Isoquinolinium,4a-(2,3-dimethoxyphenyl)-3,4,4a,5,6,7,8,8a-octahydro-2-methyl-6-oxo-,cis-, perchlorate
CAS No.:91713-06-3
Molecular Formula:C18H24NO3.ClO4
Molecular Weight:401.844
Hs Code.:

Synonyms:

Suppliers and Price of Isoquinolinium,4a-(2,3-dimethoxyphenyl)-3,4,4a,5,6,7,8,8a-octahydro-2-methyl-6-oxo-,cis-, perchlorate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Isoquinolinium,4a-(2,3-dimethoxyphenyl)-3,4,4a,5,6,7,8,8a-octahydro-2-methyl-6-oxo-,cis-, perchlorate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Isoquinolinium,4a-(2,3-dimethoxyphenyl)-3,4,4a,5,6,7,8,8a-octahydro-2-methyl-6-oxo-,cis-, perchlorate

There total 12 articles about Isoquinolinium,4a-(2,3-dimethoxyphenyl)-3,4,4a,5,6,7,8,8a-octahydro-2-methyl-6-oxo-,cis-, perchlorate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 83999-50-2
4a-(2,3-dimethoxyphenyl)-6,6-(ethylenedioxy)-2-methyl-2,3,4,4a,5,6,7,8-octahydroisoquinoline

: 91713-06-3
cis-4a-(2,3-dimethoxyphenyl)-2-methyl-6-oxo-3,4,4a,5,6,7,8,8a-octahydroisoquinolinium perchlorate

Guidance literature:: With hydrogenchloride; perchloric acid; In diethyl ether; ethanol; water;
DOI:10.1021/jo00194a026

Reference yield:

: 58529-72-9
3-isopropoxycyclohex-2-en-1-one

: 91713-06-3
cis-4a-(2,3-dimethoxyphenyl)-2-methyl-6-oxo-3,4,4a,5,6,7,8,8a-octahydroisoquinolinium perchlorate

Guidance literature:: Multi-step reaction with 12 steps

1: 1) n-BuLi, TMEDA / 1) hexane, ether, RT, 2 h, 2) RT, 18 h

2: 60 percent / 0.5 N H₂SO₄ / tetrahydrofuran / 20 h

3: p-toluenesulfonic acid monohydrate / benzene / 20 h / Heating

4: 1) BH₃, 2) 3N NaOH, 30 percent H₂O₂ / 1) THF, RT, overnight, 2a) 1 h, RT, 2b) 45 deg C, overnight

5: 88 percent / pyridinium chlorochromate / CH₂Cl₂

6: 1) NaH / 1) DME, 2) toluene, 36 h, reflux

7: 1) OsO₄, 2) NaIO₄ / 1) ether, water, 20 min, 2) 48 h

8: 90 percent / NaH, t-amyl alcohol / benzene / 0.5 h / Heating

9: 99 percent / sodium acetate / ethanol / Heating

10: 60 percent / p-toluenesulfonyl chloride / pyridine; H₂O / 0.75 h / Ambient temperature

11: 85 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

12: 91 percent / HClO₄/HCl / diethyl ether; H₂O; ethanol

With hydrogenchloride; sodium hydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; perchloric acid; tert-Amyl alcohol; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; borane; dihydrogen peroxide; sodium acetate; sodium hydride; toluene-4-sulfonic acid; p-toluenesulfonyl chloride; pyridinium chlorochromate; In tetrahydrofuran; pyridine; diethyl ether; ethanol; dichloromethane; water; benzene;
DOI:10.1021/jo00194a026

Reference yield:

: 91712-86-6
3-(2,3-dimethoxyphenyl)-2-cyclohexenone

: 91713-06-3
cis-4a-(2,3-dimethoxyphenyl)-2-methyl-6-oxo-3,4,4a,5,6,7,8,8a-octahydroisoquinolinium perchlorate

Guidance literature:: Multi-step reaction with 10 steps

1: p-toluenesulfonic acid monohydrate / benzene / 20 h / Heating

2: 1) BH₃, 2) 3N NaOH, 30 percent H₂O₂ / 1) THF, RT, overnight, 2a) 1 h, RT, 2b) 45 deg C, overnight

3: 88 percent / pyridinium chlorochromate / CH₂Cl₂

4: 1) NaH / 1) DME, 2) toluene, 36 h, reflux

5: 1) OsO₄, 2) NaIO₄ / 1) ether, water, 20 min, 2) 48 h

6: 90 percent / NaH, t-amyl alcohol / benzene / 0.5 h / Heating

7: 99 percent / sodium acetate / ethanol / Heating

8: 60 percent / p-toluenesulfonyl chloride / pyridine; H₂O / 0.75 h / Ambient temperature

9: 85 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

10: 91 percent / HClO₄/HCl / diethyl ether; H₂O; ethanol

With hydrogenchloride; sodium hydroxide; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; perchloric acid; tert-Amyl alcohol; borane; dihydrogen peroxide; sodium acetate; sodium hydride; toluene-4-sulfonic acid; p-toluenesulfonyl chloride; pyridinium chlorochromate; In tetrahydrofuran; pyridine; diethyl ether; ethanol; dichloromethane; water; benzene;
DOI:10.1021/jo00194a026